Department of Radiology, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Eur J Nucl Med Mol Imaging. 2011 Nov;38(11):2025-30. doi: 10.1007/s00259-011-1877-y. Epub 2011 Jul 15.
We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.
The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day (99m)Tc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥ 50% luminal narrowing) was calculated on a per-patient basis.
The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.
In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.
我们评估了一种新型的混合单光子发射计算机断层扫描（SPECT）/CT 设备（由超快速专用心脏伽马相机和碲化镉锌（CZT）固态半导体探测器集成在多排 CT 扫描仪上组成）在诊断冠心病（CAD）中的准确性。以有创冠状动脉造影为参考标准。
研究人群包括 66 名患者（79%为男性；平均年龄 63±11 岁），他们在 3 个月内接受了 1 天（99m）Tc-四氮茂药物应激/静息检查和血管造影。基于 CT 射线的衰减校正 CZT MPI 检测 CAD（≥50%管腔狭窄）的每例患者的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和准确性。
研究人群中血管造影 CAD 的患病率为 82%。敏感性、特异性、PPV、NPV 和准确性分别为 87%、67%、92%、53%和 83%。
在这项关于 CZT SPECT/CT MPI 与血管造影比较的首次报告中，我们证实了该方法对有创冠状动脉造影证实的 CAD 的高准确性。
