Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Am Chem Soc. 2011 Aug 24;133(33):13002-5. doi: 10.1021/ja2057852. Epub 2011 Aug 1.
A general strategy for the directed and stereocontrolled assembly of carbon-carbon linked heterodimeric hexahydropyrroloindoles is described. The stepwise union of complex amines in the form of mixed diazenes followed by photoexpulsion of dinitrogen in a solvent cage provides completely guided assembly at challenging C(sp(3))-C(sp(3)) and C(sp(3))-C(sp(2)) connections.
描述了一种用于定向和立体控制组装碳-碳连接的杂二聚体六氢吡咯并吲哚的通用策略。复杂胺以混合重氮的形式逐步结合,然后在溶剂笼中光解氮气,可在具有挑战性的 C(sp(3))-C(sp(3)) 和 C(sp(3))-C(sp(2)) 键处提供完全受控的组装。