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由丙型肝炎病毒基因组5'区域编码的一种结构蛋白能有效检测病毒感染。

A structural protein encoded by the 5' region of the hepatitis C virus genome efficiently detects viral infection.

作者信息

Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K

机构信息

Virology Division, National Cancer Center Research Institute, Tokyo.

出版信息

Jpn J Cancer Res. 1990 Nov;81(11):1092-4. doi: 10.1111/j.1349-7006.1990.tb02518.x.

DOI:10.1111/j.1349-7006.1990.tb02518.x
PMID:2176200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917981/
Abstract

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non-structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

摘要

丙型肝炎病毒基因组的一个结构区域被进行了分子克隆。通过转录后翻译在体外表达的一种蛋白质，能被慢性肝炎或肝细胞癌患者血清免疫沉淀，这些患者的血清中抗丙型肝炎病毒非结构蛋白C100抗体呈阳性，但健康人血清不能使其沉淀。因此，这种结构蛋白应有助于检测该病毒感染。

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本文引用的文献

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Identification of new gene products coded from X regions of human T-cell leukemia viruses.人类T细胞白血病病毒X区域编码的新基因产物的鉴定
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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis.一种针对人类非甲非乙型肝炎主要致病病毒的循环抗体检测方法。
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Detection of hepatitis C virus RNA in sera and liver tissues of non-A, non-B hepatitis patients using the polymerase chain reaction.运用聚合酶链反应检测非甲非乙型肝炎患者血清和肝组织中的丙型肝炎病毒RNA
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The 5'-terminal sequence of the hepatitis C virus genome.丙型肝炎病毒基因组的5'末端序列。
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Prevalence of antibody against non-A, non-B hepatitis virus in Japanese patients with hepatocellular carcinoma.日本肝细胞癌患者中抗非甲非乙型肝炎病毒抗体的流行率。
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Detection of serum hepatitis C virus RNA.血清丙型肝炎病毒RNA检测
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