由丙型肝炎病毒基因组5'区域编码的一种结构蛋白能有效检测病毒感染。
A structural protein encoded by the 5' region of the hepatitis C virus genome efficiently detects viral infection.
作者信息
Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K
机构信息
Virology Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1990 Nov;81(11):1092-4. doi: 10.1111/j.1349-7006.1990.tb02518.x.
Abstract
A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non-structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.
摘要
丙型肝炎病毒基因组的一个结构区域被进行了分子克隆。通过转录后翻译在体外表达的一种蛋白质，能被慢性肝炎或肝细胞癌患者血清免疫沉淀，这些患者的血清中抗丙型肝炎病毒非结构蛋白C100抗体呈阳性，但健康人血清不能使其沉淀。因此，这种结构蛋白应有助于检测该病毒感染。
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