Ohkoshi S, Kojima H, Tawaraya H, Miyajima T, Kamimura T, Asakura H, Satoh A, Hirose S, Hijikata M, Kato N
Third Department of Internal Medicine School of Medicine, Niigata University.
Jpn J Cancer Res. 1990 Jun-Jul;81(6-7):550-3. doi: 10.1111/j.1349-7006.1990.tb02605.x.
Antibodies against a possible causative agent of non-A, non-B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme-linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)-negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg-positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg-negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody-positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti-HCV antibody and HBsAg-negative hepatocellular carcinoma in Japan.
利用日本Ortho诊断系统公司的酶联免疫吸附测定（ELISA）系统，对日本肝细胞癌患者体内针对非甲非乙型肝炎可能致病因子丙型肝炎病毒（HCV）的抗体进行了分析。58例乙型肝炎病毒表面抗原（HBsAg）阴性的肝细胞癌患者中，50例抗体呈阳性（86%）；42例HBsAg阳性的肝细胞癌患者中，8例呈阳性（19%）。在HBsAg阴性的肝细胞癌患者中，有输血史者抗体阳性率（97%）高于无输血史者（70%）。54例非肝细胞癌患者中，仅3例抗体呈阳性（5.6%），且这3例患者均有输血史。这些结果表明，在日本，抗HCV抗体的存在与HBsAg阴性的肝细胞癌之间存在密切关系。
