Natural Products Chemistry Laboratory, College of Agriculture and Life Science, Chonnam National University, Gwangju, Republic of Korea.
Mini Rev Med Chem. 2011 Oct;11(11):947-55. doi: 10.2174/138955711797068472.
Nigella sativa L. (black cumin), commonly known as black seed, is a member of the Ranunculaceae family. This seed is used as a natural remedy in many Middle Eastern and Far Eastern countries. Extracts prepared from N. sativa have, for centuries, been used for medical purposes. Thus far, the organic compounds in N. sativa, including alkaloids, steroids, carbohydrates, flavonoids, fatty acids, etc. have been fairly well characterized. Herein, we summarize some new extraction techniques, including microwave assisted extraction (MAE) and supercritical extraction techniques (SFE), in addition to the classical method of hydrodistillation (HD), which have been employed for isolation and various analytical techniques used for the identification of secondary metabolites in black seed. We believe that some compounds contained in N. sativa remain to be identified, and that high-throughput screening could help to identify new compounds. A study addressing environmentally-friendly techniques that have minimal or no environmental effects is currently underway in our laboratory.
黑种草（黑孜然），俗称黑种子，是毛茛科的一员。这种种子在许多中东和远东国家被用作天然药物。几个世纪以来，从黑种草中提取的物质一直被用于医疗用途。到目前为止，黑种草中的有机化合物，包括生物碱、类固醇、碳水化合物、类黄酮、脂肪酸等，已经得到了很好的描述。在此，我们总结了一些新的提取技术，包括微波辅助提取（MAE）和超临界萃取技术（SFE），以及经典的水蒸馏法（HD），这些技术被用于分离和鉴定黑种草中次生代谢物的各种分析技术。我们相信，黑种草中仍有一些化合物有待鉴定，高通量筛选可能有助于鉴定新化合物。我们实验室目前正在进行一项关于环境友好技术的研究，这些技术对环境的影响最小或没有影响。
