Global Health Research Group, New Delhi, India.
Int Dent J. 2011 Aug;61 Suppl 3(Suppl 3):21-7. doi: 10.1111/j.1875-595X.2011.00045.x.
To assess the ability of 0.1%w/w o-cymen-5-ol/ 0.6%w/w zinc chloride gel to foam dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice.
Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This involved a professional dental prophylaxis supported by oral hygiene instruction prior to commencing study treatment. Subjects brushed twice daily for 12 weeks with either the test or control dentifrice. Examinations for gingival inflammation (MGI), bleeding and plaque were performed after 12 weeks.
205 subjects were included in the efficacy analysis. Relative to the sodium fluoride/ silica control dentifrice group the o-cymen-5-ol/ zinc chloride gel to foam dentifrice exhibited statistically significant reductions (p<0.0001) in MGI, bleeding and plaque of 32.2%, 26.3% and 20.7% respectively after 12 weeks.
The results of the present clinical study demonstrate that the use of the 0.1%w/w o-cymen-5-ol/ 0.6%w/w zinc chloride gel to foam dentifrice over a 12 week period provides a statistically significant benefit in maintaining gingival health compared to a sodium fluoride control dentifrice.
评估 0.1%w/w 莪术醇/0.6%w/w 氯化锌凝胶泡沫牙膏在维持牙龈健康方面相对于含氟化物牙膏的效果。
在基线检查后，研究对象进行了一个方案，使他们达到高水平的牙龈健康。这涉及到在开始研究治疗前，通过专业的牙科洁治和口腔卫生指导来支持。研究对象使用试验或对照牙膏每天刷牙两次，持续 12 周。在 12 周后进行牙龈炎症（MGI）、出血和菌斑检查。
205 名研究对象被纳入疗效分析。与含氟化物/二氧化硅对照牙膏组相比，莪术醇/氯化锌凝胶泡沫牙膏在第 12 周时分别显示出 MGI、出血和菌斑显著降低（p<0.0001），分别为 32.2%、26.3%和 20.7%。
本临床研究的结果表明，在 12 周的使用期间，使用 0.1%w/w 莪术醇/0.6%w/w 氯化锌凝胶泡沫牙膏在维持牙龈健康方面相对于含氟化物控制牙膏具有统计学上的显著益处。
