Pascual Javier, Mira Otal Javier, Torrent-Silla Daniel, Porcar Manuel, Vilanova Cristina, Vivancos Cuadras Fernando
Darwin Bioprospecting Excellence S.L., Paterna, Spain.
Lacer S. A., Barcelona, Spain.
J Oral Microbiol. 2023 Mar 3;15(1):2185962. doi: 10.1080/20002297.2023.2185962. eCollection 2023.
Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown.
To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals.
A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach.
Analysis of the oral microbiome showed that the mouthwash selectively targeted potential oral pathogens while maintaining the integrity of the rest of the microbiome. Specifically, the relative abundance of several potentially pathogenic bacterial taxa, namely , , , , , , , (nodatum group) and (SR1) decreased, while the growth of , a nitrate-reducing bacterium beneficial for blood pressure, was stimulated.
The use of o-cymen-5-ol and zinc chloride as antimicrobial agents in oral mouthwashes is a valuable alternative to classical antimicrobial agents.
漱口水内的许多抗菌化合物会对口腔微生物群产生负面影响。对伞花烃-5-醇是一种源自植物化学物质的化合物，具有靶向作用模式，正被用作一种替代物。然而，其对天然口腔微生物群的影响尚不清楚。
评估一种由对伞花烃-5-醇和氯化锌配制而成的漱口水对健康个体口腔微生物群的影响。
将一种由对伞花烃-5-醇和氯化锌配制而成的漱口水给予51名志愿者组成的队列，为期14天，而另一组49名志愿者接受安慰剂。使用宏分类学方法分析两组口腔微生物群的演变。
口腔微生物群分析表明，该漱口水在保持微生物群其他部分完整性的同时，选择性地靶向潜在的口腔病原体。具体而言，几种潜在致病细菌类群的相对丰度，即 、 、 、 、 、 、 （无数据组）和 （SR1）下降，而一种对血压有益的硝酸盐还原菌 的生长受到刺激。
在口腔漱口中使用对伞花烃-5-醇和氯化锌作为抗菌剂是传统抗菌剂的一种有价值的替代品。
