使用 DenTiUS Deep Plaque 软件分析的马鞭草醇漱口水的短期抗菌斑效果：一项随机临床试验。

Short-term anti-plaque effect of a cymenol mouthwash analysed using the DenTiUS Deep Plaque software: a randomised clinical trial.

机构信息

Oral Sciences Research Group, Special Needs Unit, Department of Surgery and Medical-Surgical Specialties, School of Medicine and Dentistry, Universidade de Santiago de Compostela, Health Research Institute of Santiago (IDIS), Santiago de Compostela, A Coruña, 15782, Spain.

Centro Singular de Investigación en Tecnoloxías Intelixentes and Departamento de Electrónica e Computación, Universidade de Santiago de Compostela, Health Research Institute of Santiago (IDIS), Santiago de Compostela, A Coruña, Spain.

出版信息

BMC Oral Health. 2023 Aug 12;23(1):560. doi: 10.1186/s12903-023-03256-9.

DOI:10.1186/s12903-023-03256-9

PMID:37573292

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10422750/

Abstract

BACKGROUND

The effect of cymenol mouthwashes on levels of dental plaque has not been evaluated thus far.

OBJECTIVE

To analyse the short-term, in situ, anti-plaque effect of a 0.1% cymenol mouthwash using the DenTiUS Deep Plaque software.

METHODS

Fifty orally healthy participants were distributed randomly into two groups: 24 received a cymenol mouthwash for eight days (test group A) and 26 a placebo mouthwash for four days and a cymenol mouthwash for a further four days thereafter (test group B). They were instructed not to perform other oral hygiene measures. On days 0, 4, and 8 of the experiment, a rinsing protocol for staining the dental plaque with sodium fluorescein was performed. Three intraoral photographs were taken per subject under ultraviolet light. The 504 images were analysed using the DenTiUS Deep Plaque software, and visible and total plaque indices were calculated (ClinicalTrials ID NCT05521230).

RESULTS

On day 4, the percentage area of visible plaque was significantly lower in test group A than in test group B (absolute = 35.31 ± 14.93% vs. 46.57 ± 18.92%, p = 0.023; relative = 29.80 ± 13.97% vs. 40.53 ± 18.48%, p = 0.024). In comparison with the placebo, the cymenol mouthwash was found to have reduced the growth rate of the area of visible plaque in the first four days by 26% (absolute) to 28% (relative). On day 8, the percentage areas of both the visible and total plaque were significantly lower in test group A than in test group B (visible absolute = 44.79 ± 15.77% vs. 65.12 ± 16.37%, p < 0.001; visible relative = 39.27 ± 14.33% vs. 59.24 ± 16.90%, p < 0.001; total = 65.17 ± 9.73% vs. 74.52 ± 13.55%, p = 0.007). Accounting for the growth rate with the placebo mouthwash on day 4, the above results imply that the cymenol mouthwash in the last four days of the trial reduced the growth rate of the area of visible plaque (absolute and relative) by 53% (test group A) and 29% (test group B), and of the area of total plaque by 48% (test group A) and 41% (test group B).

CONCLUSIONS

The 0.1% cymenol mouthwash has a short-term anti-plaque effect in situ, strongly conditioning the rate of plaque growth, even in clinical situations with high levels of dental plaque accumulation.

摘要

背景

迄今为止，还没有评估桉树脑漱口水对牙菌斑水平的影响。

目的

使用 DenTiUS Deep Plaque 软件分析 0.1%桉树脑漱口水的短期、原位抗菌斑效果。

方法

将 50 名口腔健康志愿者随机分为两组：24 名接受桉树脑漱口水漱口 8 天（试验组 A），26 名先接受安慰剂漱口 4 天，然后再接受桉树脑漱口水漱口 4 天（试验组 B）。他们被指示不进行其他口腔卫生措施。在实验的第 0、4 和 8 天，进行了使用荧光素钠对牙菌斑进行染色的冲洗方案。每个受试者拍摄 3 张口腔内照片，在紫外线下拍摄。使用 DenTiUS Deep Plaque 软件分析 504 张图像，并计算可见和总菌斑指数（ClinicalTrials ID NCT05521230）。

结果

第 4 天，试验组 A 的可见菌斑面积百分比明显低于试验组 B（绝对=35.31±14.93% vs. 46.57±18.92%，p=0.023；相对=29.80±13.97% vs. 40.53±18.48%，p=0.024）。与安慰剂相比，桉树脑漱口水在头四天将可见菌斑面积的增长率降低了 26%（绝对）至 28%（相对）。第 8 天，试验组 A 的可见和总菌斑面积百分比均明显低于试验组 B（可见绝对=44.79±15.77% vs. 65.12±16.37%，p<0.001；可见相对=39.27±14.33% vs. 59.24±16.90%，p<0.001；总=65.17±9.73% vs. 74.52±13.55%，p=0.007）。考虑到第 4 天安慰剂漱口水的增长率，上述结果表明，试验最后四天的桉树脑漱口水将可见菌斑面积的增长率（绝对和相对）降低了 53%（试验组 A）和 29%（试验组 B），总菌斑面积的增长率降低了 48%（试验组 A）和 41%（试验组 B）。