调节 HIV-1 Gag 与质膜结合的分子决定因素。
Molecular determinants that regulate plasma membrane association of HIV-1 Gag.
机构信息
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
出版信息
J Mol Biol. 2011 Jul 22;410(4):512-24. doi: 10.1016/j.jmb.2011.04.015.
Abstract
Human immunodeficiency virus type 1 assembly is a multistep process that occurs at the plasma membrane (PM). Targeting and binding of Gag to the PM are the first steps in this assembly process and are mediated by the matrix domain of Gag. This review highlights our current knowledge on viral and cellular determinants that affect specific interactions between Gag and the PM. We will discuss potential mechanisms by which the matrix domain might integrate three regulatory components, myristate, phosphatidylinositol-(4,5)-bisphosphate, and RNA, to ensure that human immunodeficiency virus type 1 assembly occurs at the PM.
摘要
人类免疫缺陷病毒 1 型的组装是一个多步骤的过程，发生在质膜（PM）上。Gag 与 PM 的靶向和结合是该组装过程的第一步，由 Gag 的基质域介导。本综述重点介绍了我们目前对影响 Gag 与 PM 之间特定相互作用的病毒和细胞决定因素的了解。我们将讨论基质域可能整合三个调节成分（豆蔻酸、磷脂酰肌醇-（4,5）-二磷酸和 RNA）的潜在机制，以确保人类免疫缺陷病毒 1 型在 PM 上组装。
相似文献
1
Molecular determinants that regulate plasma membrane association of HIV-1 Gag.调节 HIV-1 Gag 与质膜结合的分子决定因素。
J Mol Biol. 2011 Jul 22;410(4):512-24. doi: 10.1016/j.jmb.2011.04.015.
2
Relationships between MA-RNA Binding in Cells and Suppression of HIV-1 Gag Mislocalization to Intracellular Membranes.细胞内 MA-RNA 结合与抑制 HIV-1 Gag 错误定位到细胞内膜之间的关系。
J Virol. 2019 Nov 13;93(23). doi: 10.1128/JVI.00756-19. Print 2019 Dec 1.
3
Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.涉及 RNA 和脂质的拮抗机制通过基质域的高度碱性区域调节 HIV-1 Gag 膜结合。
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1600-5. doi: 10.1073/pnas.0908661107. Epub 2010 Jan 4.
4
Elucidating the mechanism by which compensatory mutations rescue an HIV-1 matrix mutant defective for gag membrane targeting and envelope glycoprotein incorporation.阐明补偿性突变拯救因gag膜靶向和包膜糖蛋白掺入缺陷的HIV-1基质突变体的机制。
J Mol Biol. 2015 Mar 27;427(6 Pt B):1413-1427. doi: 10.1016/j.jmb.2015.01.018. Epub 2015 Feb 7.
5
Phosphatidylinositol-(4,5)-Bisphosphate Acyl Chains Differentiate Membrane Binding of HIV-1 Gag from That of the Phospholipase Cδ1 Pleckstrin Homology Domain.磷脂酰肌醇 -（4,5）-二磷酸的酰基链区分HIV-1 Gag与磷脂酶Cδ1普列克底物蛋白同源结构域的膜结合。
J Virol. 2015 Aug;89(15):7861-73. doi: 10.1128/JVI.00794-15. Epub 2015 May 20.
6
The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation.HIV-1 Gag 与质膜结合和 Env 整合之间的相互作用。
Viruses. 2020 May 16;12(5):548. doi: 10.3390/v12050548.
7
Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions.HIV-1 基质-包膜细胞质尾巴相互作用分析。
J Virol. 2019 Oct 15;93(21). doi: 10.1128/JVI.01079-19. Print 2019 Nov 1.
8
Membrane Binding of HIV-1 Matrix Protein: Dependence on Bilayer Composition and Protein Lipidation.HIV-1基质蛋白的膜结合：对双层膜组成和蛋白质脂化的依赖性
J Virol. 2016 Apr 14;90(9):4544-4555. doi: 10.1128/JVI.02820-15. Print 2016 May.
9
HIV-1 Matrix Trimerization-Impaired Mutants Are Rescued by Matrix Substitutions That Enhance Envelope Glycoprotein Incorporation.HIV-1 基质三聚体形成缺陷型突变体可通过增强包膜糖蛋白整合的基质取代得到挽救。
J Virol. 2019 Dec 12;94(1). doi: 10.1128/JVI.01526-19.
10
HIV-1 matrix mutations that alter gag membrane binding modulate mature core formation and post-entry events.HIV-1 基质突变改变 gag 膜结合，调节成熟核心形成和进入后事件。
Virology. 2019 Jun;532:97-107. doi: 10.1016/j.virol.2019.04.013. Epub 2019 Apr 27.
引用本文的文献
1
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation.保守的HIV-1间隔肽2触发基质晶格成熟。
Nature. 2025 Apr;640(8057):258-264. doi: 10.1038/s41586-025-08624-9. Epub 2025 Feb 26.
2
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation.保守的HIV-1间隔肽2触发基质晶格成熟。
bioRxiv. 2024 Nov 6:2024.11.06.622200. doi: 10.1101/2024.11.06.622200.
3
HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1.HIV-1 出芽需要氧化还原酶 MICAL1 使皮质肌动蛋白解体。
Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2407835121. doi: 10.1073/pnas.2407835121. Epub 2024 Nov 18.
4
The Assembly of HTLV-1-How Does It Differ from HIV-1?HTLV-1 衣壳的组装——它与 HIV-1 有何不同？
Viruses. 2024 Sep 27;16(10):1528. doi: 10.3390/v16101528.
5
Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly.人类免疫缺陷病毒 1 型 Gag 多聚蛋白像表面活性剂一样调节膜物理性质：对病毒组装的潜在影响。
ACS Infect Dis. 2024 Aug 9;10(8):2870-2885. doi: 10.1021/acsinfecdis.4c00251. Epub 2024 Jun 25.
6
Cooperative Membrane Binding of HIV-1 Matrix Proteins.HIV-1 基质蛋白的协同膜结合。
J Phys Chem B. 2024 Mar 21;128(11):2595-2606. doi: 10.1021/acs.jpcb.3c06222. Epub 2024 Mar 13.
7
Molecular dynamics simulations of HIV-1 matrix-membrane interactions at different stages of viral maturation.HIV-1 基质-膜相互作用在病毒成熟不同阶段的分子动力学模拟。
Biophys J. 2024 Feb 6;123(3):389-406. doi: 10.1016/j.bpj.2024.01.006. Epub 2024 Jan 9.
8
Selective ablation of 3' RNA ends and processive RTs facilitate direct cDNA sequencing of full-length host cell and viral transcripts.选择性地切除 3' RNA 末端和连续 RT 有助于全长宿主细胞和病毒转录本的直接 cDNA 测序。
Nucleic Acids Res. 2022 Sep 23;50(17):e98. doi: 10.1093/nar/gkac516.
9
Advances in HIV-1 Assembly.HIV-1 组装的研究进展。
Viruses. 2022 Feb 26;14(3):478. doi: 10.3390/v14030478.
10
Visualization of Retroviral Gag-Genomic RNA Cellular Interactions Leading to Genome Encapsidation and Viral Assembly: An Overview.逆转录病毒衣壳-基因组 RNA 细胞相互作用导致基因组包装和病毒组装的可视化：概述。
Viruses. 2022 Feb 5;14(2):324. doi: 10.3390/v14020324.
本文引用的文献
1
HIV-1 Virological Synapse: Live Imaging of Transmission.HIV-1 病毒学突触：传播的实时成像。
Viruses. 2010 Aug;2(8):1666-1680. doi: 10.3390/v2081666. Epub 2010 Aug 12.
2
Cell-to-Cell Spread of Retroviruses.逆转录病毒的细胞间传播。
Viruses. 2010 Jun;2(6):1306-1321. doi: 10.3390/v2061306. Epub 2010 Jun 10.
3
T cell polarization at the virological synapse.T 细胞在病毒学突触处的极化。
Viruses. 2010 Jun;2(6):1261-1278. doi: 10.3390/v2061261. Epub 2010 May 31.
4
Gag localization and virus-like particle release mediated by the matrix domain of human T-lymphotropic virus type 1 Gag are less dependent on phosphatidylinositol-(4,5)-bisphosphate than those mediated by the matrix domain of HIV-1 Gag.人嗜 T 淋巴细胞病毒 1 衣壳蛋白基质域介导的 gag 定位和病毒样颗粒释放比 HIV-1 衣壳蛋白基质域介导的 gag 定位和病毒样颗粒释放对磷脂酰肌醇-(4,5)-二磷酸的依赖性低。
J Virol. 2011 Apr;85(8):3802-10. doi: 10.1128/JVI.02383-10. Epub 2011 Feb 2.
5
Assembly and replication of HIV-1 in T cells with low levels of phosphatidylinositol-(4,5)-bisphosphate.HIV-1 在低水平磷脂酰肌醇-(4,5)-二磷酸的 T 细胞中的组装和复制。
J Virol. 2011 Apr;85(7):3584-95. doi: 10.1128/JVI.02266-10. Epub 2011 Jan 26.
6
Phosphoinositides direct equine infectious anemia virus gag trafficking and release.磷酸肌醇指导马传染性贫血病毒衣壳蛋白的运输和释放。
Traffic. 2011 Apr;12(4):438-51. doi: 10.1111/j.1600-0854.2010.01153.x. Epub 2011 Feb 1.
7
HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid.HIV-1 Gag 延伸：构象变化需要与膜和核酸同时相互作用。
J Mol Biol. 2011 Feb 18;406(2):205-14. doi: 10.1016/j.jmb.2010.11.051. Epub 2010 Dec 4.
8
Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding.基质域通过结合肌醇磷酸盐调节 HIV-1 Gag 的核酸伴侣活性。
J Virol. 2011 Feb;85(4):1594-603. doi: 10.1128/JVI.01809-10. Epub 2010 Dec 1.
9
Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells.核衣壳蛋白促进 HIV-1 gag 定位到参与 T 细胞间病毒学突触的纤毛上。
PLoS Pathog. 2010 Oct 28;6(10):e1001167. doi: 10.1371/journal.ppat.1001167.
10
RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production.针对人类免疫缺陷病毒 1 型 Gag 多聚蛋白的 RNA 适体与基质和核衣壳结构域结合，并抑制病毒的产生。
J Virol. 2011 Jan;85(1):305-14. doi: 10.1128/JVI.02626-09. Epub 2010 Oct 27.
Zotero 插件