Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.
Viruses. 2010 Aug;2(8):1666-1680. doi: 10.3390/v2081666. Epub 2010 Aug 12.
A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
HIV-1 生物学的一个相对较新的方面是病毒通过专门结构——病毒突触，直接通过细胞接触感染细胞的能力。这一过程最近通过活细胞成像进行了描述。结合关于 HIV-1 细胞间传播所涉及的细胞和分子结构的累积知识，视频显微镜中的病毒突触可视化带来了关于其潜在机制的令人兴奋的新假设。本综述将特别强调活细胞显微镜提出的问题，回顾当前的知识。
