Department of Cardiology, Cardiovascular Research Institute, Northern Hospital, Shenyang 110084, China.
Cytokine. 2011 Nov;56(2):188-91. doi: 10.1016/j.cyto.2011.06.010. Epub 2011 Jul 16.
Acute coronary syndrome (ACS) is one of the most common forms of heart disease. Recent studies have shown that interleukin (IL)-8 plays a key role in the development of atherosclerotic plaques, but the relationship between the common genetic variants of IL-8 and ACS has not been extensively studied.
This case-control study in the Chinese Han population included 675 patients with ACS and 636 age- and sex-matched controls. We investigated IL-8 polymorphisms and their association with susceptibility to ACS. The investigation was replicated in the second study comprising 360 cases and 360 control subjects. The plasma concentration of IL-8 was measured by enzyme-linked immunosorbent assay.
IL-8 -251 A/T polymorphism was associated with increased susceptibility to ACS (P=0.004; odds ratio=1.30; 95% confidence interval: 1.12-1.53). The second study yielded similar results. An increased IL-8 level was found in the plasma of acute myocardial infarction patients, suggesting that IL-8 -251 A/T may affect the expression of IL-8.
IL-8 -251 A/T polymorphism is associated with ACS risk in the Chinese Han population and the A allele of IL-8 -251 A/T may be an independent predictive factor for ACS.
急性冠状动脉综合征（ACS）是最常见的心脏病形式之一。最近的研究表明，白细胞介素（IL）-8 在动脉粥样硬化斑块的发展中起着关键作用，但 IL-8 的常见遗传变异与 ACS 之间的关系尚未得到广泛研究。
这项在中国汉族人群中进行的病例对照研究包括 675 例 ACS 患者和 636 名年龄和性别匹配的对照者。我们研究了 IL-8 多态性及其与 ACS 易感性的关系。该研究在包括 360 例病例和 360 例对照者的第二项研究中得到了复制。通过酶联免疫吸附试验测量了 IL-8 的血浆浓度。
IL-8-251 A/T 多态性与 ACS 的易感性增加相关（P=0.004；比值比=1.30；95%置信区间：1.12-1.53）。第二项研究也得出了相似的结果。在急性心肌梗死患者的血浆中发现了较高的 IL-8 水平，提示 IL-8-251 A/T 可能影响 IL-8 的表达。
IL-8-251 A/T 多态性与中国汉族人群的 ACS 风险相关，IL-8-251 A/T 的 A 等位基因可能是 ACS 的独立预测因子。
