Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Control Release. 2011 Dec 10;156(2):239-45. doi: 10.1016/j.jconrel.2011.06.035. Epub 2011 Jul 8.
The potential of poly(propylene fumarate) (PPF) scaffolds as drug carriers was investigated and the kinetics of the drug release quantified using magnetic resonance imaging (MRI) and optical imaging. Three different MR contrast agents were used for coating PPF scaffolds. Initially, iron oxide (IONP) or manganese oxide nanoparticles (MONP) carrying the anti-cancer drug doxorubicin were absorbed or mixed with the scaffold and their release into solution at physiological conditions was measured with MRI and optical imaging. A slow (hours to days) and functional release of the drug molecules into the surrounding solution was observed. In order to examine the release properties of proteins and polypeptides, protamine sulfate, a chemical exchange saturation transfer (CEST) MR contrast agent, was attached to the scaffold. Protamine sulfate showed a steady release rate for the first 24h. Due to its biocompatibility, versatile drug-loading capability and constant release rate, the porous PPF scaffold has potential in various biomedical applications, including MR-guided implantation of drug-dispensing materials, development of drug carrying vehicles, and drug delivery for tumor treatment.
聚（富马酸丙二醇酯）（PPF）支架作为药物载体的潜力进行了研究，并使用磁共振成像（MRI）和光学成像来定量研究药物释放的动力学。使用三种不同的磁共振对比剂对 PPF 支架进行了涂层。最初，载有抗癌药物阿霉素的氧化铁（IONP）或氧化锰纳米颗粒（MONP）被吸收或与支架混合，并通过 MRI 和光学成像测量其在生理条件下释放到溶液中的情况。观察到药物分子缓慢（数小时至数天）且具有功能性地释放到周围溶液中。为了研究蛋白质和多肽的释放特性，将化学交换饱和传递（CEST）磁共振对比剂硫酸鱼精蛋白附着到支架上。硫酸鱼精蛋白在前 24 小时内表现出稳定的释放速率。由于其生物相容性、多功能的药物负载能力和恒定的释放速率，多孔 PPF 支架具有在各种生物医学应用中的潜力，包括用于磁共振引导植入药物释放材料、开发载药载体以及用于肿瘤治疗的药物输送。
