Departamento de Medicina y Cirugía Animal, Universidad de Murcia, Campus de Espinardo, Espinardo, Murcia 30100, Spain.
Vet J. 2012 May;192(2):189-92. doi: 10.1016/j.tvjl.2011.05.021. Epub 2011 Jul 20.
Balanced anaesthesia techniques employ specific drugs in addition to general anaesthetics. The potential effect of some of these drugs on the bispectral index (BIS) remains unclear. BIS seems to be unaffected by the administration of neuromuscular blockers while opioids may block nociceptive-induced BIS increases in anaesthetized humans. In this study, the effect of a single dose of atracurium on BIS values was assessed in dogs premedicated with morphine and anaesthetized with isoflurane (1 MAC). Fifteen female dogs undergoing elective ovariohysterectomy were employed. BIS values were recorded before and after the administration of atracurium. These values were then recorded again once the animals were surgically stimulated. The end tidal isoflurane concentration, cardiovascular and respiratory parameters were recorded through the study. Results show that the mean (±SD) BIS values decreased slightly, but significantly (P=0.033) from 67±8.42 to 65±5.84 after the administration of atracurium. Despite significant increase in heart rate and arterial pressure during the surgical phase, the mean BIS values were not modified by ovariohysterectomy. Atracurium appeared to have minimal clinical effect on the BIS in anaesthetized dogs.
平衡麻醉技术除了使用全身麻醉剂外，还使用特定的药物。这些药物中的一些对双频谱指数（BIS）的潜在影响尚不清楚。BIS 似乎不受神经肌肉阻滞剂的影响，而阿片类药物可能会阻止麻醉状态下人类的伤害性刺激引起的 BIS 增加。在这项研究中，评估了在吗啡预处理和异氟烷（1 MAC）麻醉的犬中单次给予阿曲库铵对 BIS 值的影响。共纳入 15 只接受择期卵巢子宫切除术的雌性犬。在给予阿曲库铵前后记录 BIS 值。然后，在动物接受手术刺激后再次记录这些值。在整个研究过程中记录呼气末异氟烷浓度、心血管和呼吸参数。结果表明，阿曲库铵给药后，BIS 值从 67±8.42 略微但显著（P=0.033）下降至 65±5.84。尽管在手术阶段心率和动脉压显著增加，但卵巢子宫切除术并未改变平均 BIS 值。阿曲库铵似乎对麻醉犬的 BIS 有最小的临床影响。
