de Mattos-Junior Ewaldo, Ito Kelly C, Conti-Patara Andreza, de Carvalho Haley da Silva, Reinoldes Adriane, Caldeira Juliana de Araújo, Cortopassi Silvia R G
Department of Veterinary Surgery, School of Veterinary Medicine and Zootechnics, University of São Paulo, Av. Prof. Orlando Marques de Paiva 87,São Paulo, SP, Brazil.
Vet Anaesth Analg. 2011 Sep;38(5):475-83. doi: 10.1111/j.1467-2995.2011.00646.x.
To assess the effect of halothane (H), isoflurane (I) or sevoflurane (S) on the bispectral index (BIS), and the effect of the addition of meperidine in dogs subjected to ovariohysterectomy.
Prospective, randomized, blinded, clinical trial.
Forty-eight female mixed-breed dogs, with weights varying from 10 to 25 kg.
All dogs were premedicated with acepromazine (A) (0.1 mg kg(-1) IM) or A and meperidine (M) (3 mg kg(-1) IM) and they were divided into six groups of eight animals (AH, AMH, AI, AMI, AS, and AMS). Fifteen minutes after premedication they were anesthetized with propofol (5 mg kg(-1) IV) and then orotracheally intubated. Anesthesia was maintained with halothane, isoflurane or sevoflurane, respectively. The BIS, variables were recorded at 15 minutes after administering pre-anesthetic medication (T0); 10 minutes of anesthesia maintenance (T1); right ovarian pedicle ligation (T2); muscle suturing (T3); skin suture (T4) and 10 minutes after terminating the inhalant anesthetic (T5), respectively.
BIS values were decreased at all times when compared to the baseline values in all groups (p<0.05). In the comparative assessment between groups, the values obtained at T0 and T1 were similar for all groups. At T2, the values in AMH were lower than those obtained in AI, AMI and AS (p<0.05). At the same time significantly higher values were found for AI when compared to AMS (p<0.01). There was a correlation between the bispectral index and the expired anesthetic fraction in all groups.
Within groups given the same inhalant anesthetic the bispectral index was a good indicator for the degree of hypnosis in dogs, indicating a good correlation with the amount of anesthetic and the nociceptive stimulation. BIS was a less reliable indicator of relative anesthetic depth when comparing equipotent end-tidal concentrations between the three inhalants.
评估氟烷（H）、异氟烷（I）或七氟烷（S）对脑电双频指数（BIS）的影响，以及在接受卵巢子宫切除术的犬中添加哌替啶的效果。
前瞻性、随机、双盲临床试验。
48只体重在10至25千克之间的雌性杂种犬。
所有犬均用乙酰丙嗪（A）（0.1毫克/千克，肌肉注射）或A与哌替啶（M）（3毫克/千克，肌肉注射）进行术前用药，并分为六组，每组8只动物（AH、AMH、AI、AMI、AS和AMS）。术前用药15分钟后，用丙泊酚（5毫克/千克，静脉注射）麻醉，然后经口气管插管。分别用氟烷、异氟烷或七氟烷维持麻醉。在给予麻醉前用药后15分钟（T0）、麻醉维持10分钟（T1）、右侧卵巢蒂结扎（T2）、肌肉缝合（T3）、皮肤缝合（T4）以及吸入麻醉剂结束后10分钟（T5）记录BIS等变量。
与所有组的基线值相比，各时间点的BIS值均降低（p<0.05）。在组间比较评估中，所有组在T0和T1时获得的值相似。在T2时，AMH组的值低于AI、AMI和AS组（p<0.05）。同时，与AMS组相比，AI组的值显著更高（p<0.01）。所有组的脑电双频指数与呼出麻醉剂分数之间存在相关性。
在给予相同吸入麻醉剂的组内，脑电双频指数是犬催眠程度的良好指标，表明与麻醉剂量和伤害性刺激有良好的相关性。在比较三种吸入剂等效的呼气末浓度时，BIS作为相对麻醉深度的指标不太可靠。
