黄曲霉毒素对大鼠腹腔巨噬细胞的影响。
Effect of aflatoxins on rat peritoneal macrophages.
作者信息
Cusumano V, Costa G B, Seminara S
机构信息
Microbiology Institute, Medical School, University of Messina, Italy.
出版信息
Appl Environ Microbiol. 1990 Nov;56(11):3482-4. doi: 10.1128/aem.56.11.3482-3484.1990.
Abstract
Phagocytosis, intracellular killing of Candida albicans, and superoxide production by rat peritoneal macrophages exposed to aflatoxins B1, B2, G1, G2, B2a, and M1 at several times and concentrations were analyzed to evaluate the intensity of a depressive effect for each mycotoxin. All aflatoxins used at very low concentrations had a depressive effect on the functions of macrophages. The biggest impairment of phagocytosis, intracellular killing, and spontaneous superoxide production was observed in macrophages exposed to aflatoxins B1 and M1.
摘要
分析了大鼠腹腔巨噬细胞在不同次数和浓度下暴露于黄曲霉毒素B1、B2、G1、G2、B2a和M1时的吞噬作用、白色念珠菌的细胞内杀伤以及超氧化物的产生，以评估每种霉菌毒素抑制作用的强度。所有极低浓度使用的黄曲霉毒素均对巨噬细胞功能有抑制作用。在暴露于黄曲霉毒素B1和M1的巨噬细胞中，观察到吞噬作用、细胞内杀伤和自发超氧化物产生的最大损伤。
相似文献
1
Effect of aflatoxins on rat peritoneal macrophages.黄曲霉毒素对大鼠腹腔巨噬细胞的影响。
Appl Environ Microbiol. 1990 Nov;56(11):3482-4. doi: 10.1128/aem.56.11.3482-3484.1990.
2
Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide.通过注射胞壁酰二肽激活巨噬细胞以增强超氧阴离子的释放及对白色念珠菌的杀伤作用。
J Exp Med. 1980 Dec 1;152(6):1659-69. doi: 10.1084/jem.152.6.1659.
3
Functional impairment of rat Kupffer cells induced by aflatoxin B1 and its metabolites.
FEMS Immunol Med Microbiol. 1995 Jan;10(2):151-5. doi: 10.1111/j.1574-695X.1995.tb00025.x.
4
Interaction and intracellular killing of Candida albicans blastospores by human polymorphonuclear leucocytes, monocytes and monocyte-derived macrophages in aerobic and anaerobic conditions.在需氧和厌氧条件下，人类多形核白细胞、单核细胞及单核细胞衍生巨噬细胞对白色念珠菌芽生孢子的相互作用及细胞内杀伤作用
Clin Exp Immunol. 1992 Feb;87(2):316-21. doi: 10.1111/j.1365-2249.1992.tb02994.x.
5
Oxygen-independent killing by alveolar macrophages.肺泡巨噬细胞的非氧依赖性杀伤作用。
J Exp Med. 1986 May 1;163(5):1113-31. doi: 10.1084/jem.163.5.1113.
6
Functional and biochemical properties of rat Kupffer cells and peritoneal macrophages.大鼠库普弗细胞和腹膜巨噬细胞的功能及生化特性
J Leukoc Biol. 1988 Aug;44(2):71-8. doi: 10.1002/jlb.44.2.71.
7
Candidacidal activity of monocyte-derived human macrophages: relationship between Candida killing and oxygen radical generation by human macrophages.单核细胞衍生的人巨噬细胞的杀念珠菌活性：人巨噬细胞杀灭念珠菌与氧自由基生成之间的关系。
J Leukoc Biol. 1987 Apr;41(4):289-94. doi: 10.1002/jlb.41.4.289.
8
Destruction of phagocytosis-suppressing activity of aflatoxin B1 by ozone.臭氧对黄曲霉毒素B1吞噬作用抑制活性的破坏。
Lett Appl Microbiol. 1993 Aug;17(2):52-4. doi: 10.1111/j.1472-765x.1993.tb00368.x.
9
In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of murine peritoneal macrophages.
Mycopathologia. 1992 Nov;120(2):121-7. doi: 10.1007/BF00578297.
10
Generation of superoxide anion and candidacidal activity by lipopolysaccharide-treated macrophages from patients affected by neoplasia.肿瘤患者经脂多糖处理的巨噬细胞中超氧阴离子的产生及杀念珠菌活性
J Chemother. 1992 Feb;4(1):35-40. doi: 10.1080/1120009x.1992.11739136.
引用本文的文献
1
Metabolic Disruption by Naturally Occurring Mycotoxins in Circulation: A Focus on Vascular and Bone Homeostasis Dysfunction.循环中天然存在的霉菌毒素引起的代谢紊乱：聚焦血管和骨内稳态功能障碍
Front Nutr. 2022 Jun 24;9:915681. doi: 10.3389/fnut.2022.915681. eCollection 2022.
2
Transcriptional Profiling of Aflatoxin B1-Induced Oxidative Stress and Inflammatory Response in Macrophages.黄曲霉毒素 B1 诱导巨噬细胞氧化应激和炎症反应的转录组学分析。
Toxins (Basel). 2021 Jun 4;13(6):401. doi: 10.3390/toxins13060401.
3
Fungal Toxins and Host Immune Responses.真菌毒素与宿主免疫反应
Front Microbiol. 2021 Apr 13;12:643639. doi: 10.3389/fmicb.2021.643639. eCollection 2021.
4
Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action.黄曲霉毒素的慢性和急性毒性：作用机制。
Int J Environ Res Public Health. 2020 Jan 8;17(2):423. doi: 10.3390/ijerph17020423.
5
Molecular Insights Into Development and Virulence Determinants of : A Proteomic Perspective.从蛋白质组学角度看 ：发育和毒力决定因素的分子洞察。
Front Cell Infect Microbiol. 2018 May 29;8:180. doi: 10.3389/fcimb.2018.00180. eCollection 2018.
6
The cytotoxicity of aflatoxin b1 in human lymphocytes.黄曲霉毒素B1对人淋巴细胞的细胞毒性。
Sultan Qaboos Univ Med J. 2014 Feb;14(1):e65-71. doi: 10.12816/0003338. Epub 2014 Jan 27.
7
A Protective Mechanism in Lungs of Rats Experimentally Infected with Aspergillus fumigatus.烟曲霉实验性感染大鼠肺部的一种保护机制
Mycobiology. 2011 Mar;39(1):40-4. doi: 10.4489/MYCO.2011.39.1.040. Epub 2011 Mar 23.
8
Role of germination in murine airway CD8+ T-cell responses to Aspergillus conidia.萌发在鼠气道 CD8+ T 细胞对曲霉菌孢子反应中的作用。
PLoS One. 2011 Apr 13;6(4):e18777. doi: 10.1371/journal.pone.0018777.
本文引用的文献
1
Impairment of phagocytosis by heterophils from chickens during ochratoxicosis.赭曲霉毒素中毒期间鸡异嗜性白细胞吞噬作用的损伤
Appl Environ Microbiol. 1980 Mar;39(3):572-5. doi: 10.1128/aem.39.3.572-575.1980.
2
Effect of T-2 toxin on adrenocortical function and immune response in growing pigs.T-2毒素对生长猪肾上腺皮质功能和免疫反应的影响。
Zentralbl Veterinarmed B. 1982 Aug;29(7):558-65. doi: 10.1111/j.1439-0450.1982.tb01255.x.
3
Mycotoxins: a review of biological effects and their role in human diseases.霉菌毒素：生物效应及其在人类疾病中的作用综述
Clin Toxicol. 1980 Aug;17(1):45-83. doi: 10.3109/15563658008985070.
4
Mycotoxins and animal health.霉菌毒素与动物健康。
Adv Vet Sci Comp Med. 1981;25:185-243.
5
Impairment of the reticuloendothelial system of chickens during aflatoxicosis.黄曲霉毒素中毒期间鸡网状内皮系统的损伤
Poult Sci. 1973 May;52(3):1206-7. doi: 10.3382/ps.0521206.
6
Effect of aflatoxin on phagocytosis of Aspergillus fumigatus spores by rabbit alveolar macrophages.黄曲霉毒素对兔肺泡巨噬细胞吞噬烟曲霉菌孢子的影响。
Appl Microbiol. 1975 Jul;30(1):44-7. doi: 10.1128/am.30.1.44-47.1975.
7
Superoxide production by phagocytic leukocytes.吞噬性白细胞产生超氧化物。
J Exp Med. 1975 Jan 1;141(1):257-62. doi: 10.1084/jem.141.1.257.
8
Impairment of phagocytosis in chicken monocytes during aflatoxicosis.
Poult Sci. 1979 May;58(3):562-6. doi: 10.3382/ps.0580562.
9
Refractory phagocytosis by chicken thrombocytes during aflatoxicosis.
Poult Sci. 1979 May;58(3):559-61. doi: 10.3382/ps.0580559.
10
Impaired phagocytosis by heterophils from chickens during aflatoxicosis.黄曲霉毒素中毒期间鸡的异嗜性白细胞吞噬作用受损。
Toxicol Appl Pharmacol. 1979 May;48(3):459-66. doi: 10.1016/0041-008x(79)90429-0.
Zotero 插件