石杉碱他汀，组织蛋白酶 B 的抑制剂，来源于海洋海绵 Crella（Yvesia）spinulata。

Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata.

机构信息

Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

出版信息

Bioorg Med Chem. 2011 Nov 15;19(22):6594-8. doi: 10.1016/j.bmc.2011.06.052. Epub 2011 Jun 24.

DOI:10.1016/j.bmc.2011.06.052

PMID:21764589

Abstract

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC(50) value of 8 μg/mL each.

摘要

从海洋海绵 Crella (Yvesia) spinulata 中分离得到两种二聚甾体衍生物，分别为 shishicrellastatin A（1）和 B（2），它们是组织蛋白酶 B 的抑制剂。通过对光谱数据的解释确定了它们的结构。shishicrellastatins 对组织蛋白酶 B 的抑制作用的 IC50 值均为 8 μg/mL。