温度和氯离子对依那普利拉和雷米普利拉对血管紧张素I转换酶稳态抑制的影响。
Effect of temperature and chloride on steady-state inhibition of angiotensin I-converting enzyme by enalaprilat and ramiprilat.
作者信息
Skoglof A, Göthe P O, Deinum J
机构信息
Department of Biochemistry and Biophysics, Chalmers University of Technology, Göteborg, Sweden.
出版信息
Biochem J. 1990 Dec 1;272(2):415-9. doi: 10.1042/bj2720415.
Abstract
The kinetics of the steady-state inhibition of angiotension I-converting enzyme (EC 3.4.15.1) at 25 degrees C and 37 degrees C with enalaprilat and ramiprilat can be simulated, assuming only one inhibitor-binding site, consistent with a 1:1 stoichiometry if the protein concentration was determined by amino acid analysis. In this temperature range the apparent inhibition constants for ramiprilat and enalaprilat were roughly doubled by a decrease in the chloride concentration from 0.300 M to 0.120 M.
摘要
假设只有一个抑制剂结合位点，在25摄氏度和37摄氏度下，依那普利拉和雷米普利拉对血管紧张素I转换酶（EC 3.4.15.1）稳态抑制的动力学可以被模拟，如果通过氨基酸分析确定蛋白质浓度，则符合1:1化学计量比。在这个温度范围内，当氯化物浓度从0.300 M降至0.120 M时，雷米普利拉和依那普利拉的表观抑制常数大约会加倍。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Regression analysis, experimental error, and statistical criteria in the design and analysis of experiments for discrimination between rival kinetic models.用于区分竞争动力学模型的实验设计与分析中的回归分析、实验误差和统计标准。
Methods Enzymol. 1982;87:370-90. doi: 10.1016/s0076-6879(82)87023-7.
3
Molecular and catalytic properties of rabbit testicular dipeptidyl carboxypeptidase.兔睾丸二肽基羧肽酶的分子与催化特性
J Biol Chem. 1982 Dec 10;257(23):14128-33.
4
Affinity chromatographic purification of angiotensin converting enzyme.血管紧张素转换酶的亲和层析纯化
Biochemistry. 1984 Feb 28;23(5):1037-42. doi: 10.1021/bi00300a036.
5
Rabbit pulmonary angiotensin-converting enzyme: the NH2-terminal fragment with enzymatic activity and its formation from the native enzyme by NH4OH treatment.兔肺血管紧张素转换酶：具有酶活性的NH2末端片段及其通过NH4OH处理由天然酶形成的过程。
Arch Biochem Biophys. 1983 Nov;227(1):188-201. doi: 10.1016/0003-9861(83)90362-4.
6
Substrate specificity and kinetic characteristics of angiotensin converting enzyme.
Biochemistry. 1983 Jan 4;22(1):103-10. doi: 10.1021/bi00270a015.
7
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Biochim Biophys Acta. 1969;185(2):269-86. doi: 10.1016/0005-2744(69)90420-3.
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