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基于多物理场磁共振成像的具有不同贴片材料的人体左右心室两层流固相互作用各向异性模型:心功能评估与机械应力分析

Multi-Physics MRI-Based Two-Layer Fluid-Structure Interaction Anisotropic Models of Human Right and Left Ventricles with Different Patch Materials: Cardiac Function Assessment and Mechanical Stress Analysis.

作者信息

Tang Dalin, Yang Chun, Geva Tal, Gaudette Glenn, Del Nido Pedro J

机构信息

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609.

出版信息

Comput Struct. 2011 Jun;89(11-12):1059-1068. doi: 10.1016/j.compstruc.2010.12.012.

Abstract

Multi-physics right and left ventricle (RV/LV) fluid-structure interaction (FSI) models were introduced to perform mechanical stress analysis and evaluate the effect of patch materials on RV function. The FSI models included three different patch materials (Dacron scaffold, treated pericardium, and contracting myocardium), two-layer construction, fiber orientation, and active anisotropic material properties. The models were constructed based on cardiac magnetic resonance (CMR) images acquired from a patient with severe RV dilatation and solved by ADINA. Our results indicate that the patch model with contracting myocardium leads to decreased stress level in the patch area, improved RV function and patch area contractility.

摘要

引入多物理场左右心室(RV/LV)流固耦合(FSI)模型来进行机械应力分析,并评估补片材料对右心室功能的影响。这些FSI模型包括三种不同的补片材料(涤纶支架、处理过的心包和收缩期心肌)、双层结构、纤维取向和活性各向异性材料特性。这些模型基于从一名严重右心室扩张患者获取的心脏磁共振(CMR)图像构建,并由ADINA求解。我们的结果表明,具有收缩期心肌的补片模型可导致补片区域的应力水平降低、右心室功能改善以及补片区域收缩性增强。

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