Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Dermatol Surg. 2011 Oct;37(10):1394-411. doi: 10.1111/j.1524-4725.2011.02088.x. Epub 2011 Jul 18.
Squamous cell carcinoma in situ (SCCIS) is thought to be a precursor to squamous cell carcinoma. It should be treated before invasive cancer develops, especially in transplant recipients, who may develop more aggressive skin cancers. Treatment can involve surgical and nonsurgical methods. OBJECTIVE To review the evidence available in the English medical literature for different treatment options of SCCIS on nongenital skin and evaluate the efficacy of each option.
A Pubmed search of articles describing the treatment of SCCIS was conducted. Keywords were "treatment," "Bowen's disease," and "squamous cell carcinoma in situ." Articles describing the use of surgical excision, curettage and electrodesiccation, cryotherapy, 5-fluorouracil, imiquimod, radiation, photodynamic therapy, lasers, and rarer methods were reviewed.
No single treatment can be said to be superior for any one situation. Most studies are small, limiting the power of each. Further studies are needed to clarify optimal treatment protocols for nonsurgical methods such as cryotherapy, photodynamic therapy, and topical chemotherapy.
There are many methods available to treat SCCIS. Physicians should consider each patient's situation while keeping in mind that treatment protocols have not been fully defined for most options. The authors have indicated no significant interest with commercial supporters.
原位鳞状细胞癌（SCCIS）被认为是鳞状细胞癌的前身。在浸润性癌症发展之前，应进行治疗，特别是在可能发展出更具侵袭性皮肤癌的移植受者中。治疗可以包括手术和非手术方法。目的：回顾英文医学文献中关于非生殖器皮肤 SCCIS 不同治疗选择的证据，并评估每种选择的疗效。
对描述 SCCIS 治疗的文章进行了 Pubmed 搜索。关键词是“治疗”、“鲍恩病”和“原位鳞状细胞癌”。综述了描述手术切除、刮除和电灼、冷冻疗法、5-氟尿嘧啶、咪喹莫特、放疗、光动力疗法、激光以及更罕见方法的使用的文章。
不能说任何一种单一的治疗方法在任何一种情况下都是优越的。大多数研究规模较小，限制了每一项研究的效力。需要进一步的研究来阐明冷冻疗法、光动力疗法和局部化疗等非手术方法的最佳治疗方案。
有许多方法可用于治疗 SCCIS。医生应考虑每位患者的情况，同时牢记大多数选择的治疗方案尚未完全确定。作者表示与商业支持者没有重大利益关系。
