Mukherjee Tathagata, Hanes Jeremiah, Tews Ivo, Ealick Steven E, Begley Tadhg P
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Biochim Biophys Acta. 2011 Nov;1814(11):1585-96. doi: 10.1016/j.bbapap.2011.06.018. Epub 2011 Jul 8.
Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.
维生素B6是一种必需的辅因子，参与大量的生化反应。磷酸吡哆醛可通过两条不同的途径（依赖1-脱氧-D-木酮糖-5-磷酸的途径和核糖-5-磷酸途径）从头生物合成，也可从环境中回收利用。它是少数几种分解代谢途径已被全面表征的辅因子之一。已知它还可作为单线态氧清除剂，对真菌中的氧化应激具有保护作用。利用维生素B6的酶是治疗药物的重要靶点。本综述简要概述了维生素B6生物合成和分解代谢的机制酶学。本文是名为“磷酸吡哆醛酶学”的特刊的一部分。
