生殖细胞中的 RNA 颗粒。
RNA granules in germ cells.
机构信息
Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12):a002774. doi: 10.1101/cshperspect.a002774.
Abstract
"Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development. In this review, we focus on recent advances in our understanding of germ granule assembly, dynamics, and function. One hypothesis is that germ granules operate as hubs for the posttranscriptional control of gene expression, a function at the core of the germ cell differentiation program.
摘要
“生殖质颗粒”是一种细胞质、非膜结合的细胞器，仅存在于生殖系细胞中。生殖质颗粒与体细胞中的 P 体和应激颗粒共享成分，但也包含对生殖细胞发育至关重要的蛋白质和 RNA。在这篇综述中，我们重点介绍了对生殖质颗粒组装、动态和功能的最新理解进展。一个假设是，生殖质颗粒作为基因表达的转录后调控的枢纽发挥作用，这是生殖细胞分化程序的核心功能。
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