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从牛膝根中分离得到的三种新的呋喃环甾体类化合物

Three new phytoecdysteroids containing a furan ring from the roots of Achyranthes bidentata Bl.

机构信息

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine), Ministry of Education, No. 24 HePing Road, XiangFang District, Harbin 150040, China.

出版信息

Molecules. 2011 Jul 18;16(7):5989-97. doi: 10.3390/molecules16075989.

DOI:10.3390/molecules16075989
PMID:21769064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264565/
Abstract

Three new phytoecdysteroid compounds, named niuxixinsterone A (1), B (2) and C (3) with acetal functions in the side-chain were isolated from Achyranthes bidentata Bl. The structures were established as (20R,22R,24S)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β,3β,14α,25-tetrahydroxy-5β-ergost-7-en-6-one (1), (20R,22R)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β,3β,25-trihydroxy-14β-methyl-18-nor-5β-cholesta-7,12-dien-6-one (2) and (20R,22R,25R)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β, 3β,5β,14α,26-pentahydroxycholest-7-en-6-one (3) by means of spectroscopic evidence.

摘要

从牛膝中分离得到三种新的植物甾醇化合物，命名为牛心甾酮 A（1）、B（2）和 C（3），它们在侧链上具有缩醛功能。通过光谱证据确定它们的结构分别为（20R,22R,24S）-20-O,22-O-（5'-羟甲基）-糠醛基-2β,3β,14α,25-四羟基-5β-麦角甾-7-烯-6-酮（1）、（20R,22R）-20-O,22-O-（5'-羟甲基）-糠醛基-2β,3β,25-三羟基-14β-甲基-18-降-5β-胆甾-7,12-二烯-6-酮（2）和（20R,22R,25R）-20-O,22-O-（5'-羟甲基）-糠醛基-2β,3β,5β,14α,26-五羟基胆甾-7-烯-6-酮（3）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/c77134d7571b/molecules-16-05989-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/b54a680b42e8/molecules-16-05989-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/25f3e5ea09c8/molecules-16-05989-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/c77134d7571b/molecules-16-05989-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/b54a680b42e8/molecules-16-05989-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/25f3e5ea09c8/molecules-16-05989-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d27b/6264565/c77134d7571b/molecules-16-05989-g003.jpg

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