从牛膝根中分离得到的三种新的呋喃环甾体类化合物

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine), Ministry of Education, No. 24 HePing Road, XiangFang District, Harbin 150040, China.

Molecules. 2011 Jul 18;16(7):5989-97. doi: 10.3390/molecules16075989.

Three new phytoecdysteroid compounds, named niuxixinsterone A (1), B (2) and C (3) with acetal functions in the side-chain were isolated from Achyranthes bidentata Bl. The structures were established as (20R,22R,24S)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β,3β,14α,25-tetrahydroxy-5β-ergost-7-en-6-one (1), (20R,22R)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β,3β,25-trihydroxy-14β-methyl-18-nor-5β-cholesta-7,12-dien-6-one (2) and (20R,22R,25R)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β, 3β,5β,14α,26-pentahydroxycholest-7-en-6-one (3) by means of spectroscopic evidence.

从牛膝中分离得到三种新的植物甾醇化合物，命名为牛心甾酮 A（1）、B（2）和 C（3），它们在侧链上具有缩醛功能。通过光谱证据确定它们的结构分别为（20R,22R,24S）-20-O,22-O-（5'-羟甲基）-糠醛基-2β,3β,14α,25-四羟基-5β-麦角甾-7-烯-6-酮（1）、（20R,22R）-20-O,22-O-（5'-羟甲基）-糠醛基-2β,3β,25-三羟基-14β-甲基-18-降-5β-胆甾-7,12-二烯-6-酮（2）和（20R,22R,25R）-20-O,22-O-（5'-羟甲基）-糠醛基-2β,3β,5β,14α,26-五羟基胆甾-7-烯-6-酮（3）。