一种来自牛膝根的新型植物蜕皮甾体

A new phytoecdysteroid from the roots of Achyranthes bidentata Bl.

作者信息

Yang Liu, Jiang Hai, Yan Mei-Ling, Xing Xu-Dong, Zhang Yan-Yan, Wei Na, Yang Bing-You, Wang Qiu-Hong, Kuang Hai-Xue

机构信息

a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.

b Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.

出版信息

Nat Prod Res. 2017 May;31(9):1073-1079. doi: 10.1080/14786419.2016.1272114. Epub 2016 Dec 29.

DOI:10.1080/14786419.2016.1272114

PMID:28033715

Abstract

A new phytoecdysteroid compound, named Niuxixinsterone D (1), together with two known phytoecdysteroid compounds (2 and 3) were isolated from Achyranthes bidentata Bl.. The structure of the new compound was elucidated by extensive spectral analysis, including HR-ESI-MS, 1D and 2D NMR methods. Compounds 1-3 were tested for their inhibitory effects against LPS-induced NO production in RAW 264.7 macrophages, and compound 1 and 3 exhibited anti-neuroinflammatory activity with inhibited 29.7 and 26.0% NO production.

摘要

从牛膝中分离出一种新的植物蜕皮甾酮化合物，命名为牛膝新甾酮D（1），以及两种已知的植物蜕皮甾酮化合物（2和3）。通过广泛的光谱分析，包括高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振方法，阐明了新化合物的结构。测试了化合物1-3对RAW 264.7巨噬细胞中脂多糖诱导的一氧化氮（NO）产生的抑制作用，化合物1和3表现出抗神经炎症活性，抑制NO产生的比例分别为29.7%和26.0%。