通过 STIM 蛋白感知细胞应激。
Sensing cellular stress through STIM proteins.
机构信息
Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Nat Chem Biol. 2011 Jul 18;7(8):488-92. doi: 10.1038/nchembio.619.
Abstract
In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.
摘要
针对内质网中钙离子水平的降低，STIM 蛋白与质膜中的 Orai 通道偶联，导致钙离子内流入细胞。除了与钙离子相关的内质网应激外，STIM 蛋白还作为一般应激传感器出现，它们可以对多种应激信号做出反应，从而协调钙离子信号和稳态。
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