刺激钙感应和构象变化。
STIM calcium sensing and conformational change.
机构信息
Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.
Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, Brasil.
出版信息
J Physiol. 2020 May;598(9):1695-1705. doi: 10.1113/JP276524. Epub 2019 Jul 11.
Abstract
The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM.
摘要
内质网 (ER) 钙库对质膜钙离子内流的控制，这是一种在无脊椎动物和脊椎动物中都很常见的过程，是生理钙信号传递和细胞钙平衡的核心。基质相互作用分子 1 (STIM1) 是一种位于内质网的钙传感器和调节蛋白。ORAI1 是质膜 (PM) 中的钙通道。简而言之，STIM1 感知内质网腔钙减少，重新定位到内质网-质膜连接处，募集和门控 ORAI1 通道。这里综述的最新工作提供了对感知和沟通内质网钙库耗竭过程的详细了解，特别是对 STIM1 构象变化的了解，这是内质网和质膜之间通讯的基础。
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本文引用的文献
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Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm.卷曲螺旋形成将 STIM1 信号从内质网腔传递到细胞质。
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Store-Operated Calcium Channels.储存式钙通道
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Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating.在储存耗竭期间，PI(4,5)P2含量低和PI(4,5)P2含量高的微结构域之间的易位决定了STIM1的构象和Orai1的门控。
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