Cornellison Cd, Dyer Jm, Plowman Je, Krsinic Gl, Clerens S
Protein Quality and Function, AgResearch Ltd, New Zealand.
Int J Trichology. 2011 Jan;3(1):25-7. doi: 10.4103/0974-7753.82127.
Lipids are an amazingly diverse group of biomolecules with an array of biological functions including protecting and maintaining key properties and structure. Oxidative insult in the form of UV, hydrothermal, or other damage leads to compromised lipid function and can be linked to a wide range of consumer complaints. This proof-of-principle study applied and evaluated redox lipidomic approaches for the characterization and profiling of selected lipids and their oxidation products in human hair. It was observed that cholesterol and cholesterol derivatives regions appeared to be the most susceptible to oxidative damage and this leads to further experiments, including the systematic characterization of oxidative products, and correlation of modifications with damage protocol.
脂质是一类极其多样的生物分子，具有一系列生物学功能，包括保护和维持关键特性及结构。紫外线、水热作用或其他形式的氧化损伤会导致脂质功能受损，并可能与多种消费者投诉问题相关联。这项原理验证研究应用并评估了氧化还原脂质组学方法，用于表征和分析人发中选定脂质及其氧化产物。研究发现胆固醇及其衍生物区域似乎最易受到氧化损伤，这引发了进一步的实验，包括对氧化产物的系统表征以及损伤模式与修饰之间的相关性研究。
