Department of Ophthalmology, Shinoda General Hospital, Yamagata, Japan.
Metab Syndr Relat Disord. 2011 Dec;9(6):427-32. doi: 10.1089/met.2011.0042. Epub 2011 Jul 19.
Retinal microvasculature provides a direct means to assess microvascular health in vivo. We examined whether retinal vessel caliber is associated with the presence of metabolic syndrome in Japanese adults in a health screening program.
We examined 1,003 Japanese adults through the health screening program conducted at the Shinoda General Hospital. Retinal vessel caliber was measured from digital fundus images using validated, semiautomated computer-assisted software. Metabolic syndrome was defined according to the definition proposed by the Joint Interim Statement in 2009. Cross-sectional associations between retinal vascular caliber and metabolic syndrome or its individual components were determined as odds ratios (ORs) using multiple logistic regression models.
The overall prevalence of metabolic syndrome in the study sample was 29.9%. Persons with increased waist circumference and elevated triglycerides and blood pressure had significantly narrower retinal arterial diameters. Persons with increased waist circumference also had wider retinal venular diameters. Narrower retinal arterial diameters and wider retinal venular diameters were associated with a higher prevalence of metabolic syndrome (OR per -1 standard deviation (SD) change in arteriolar caliber=2.15, 95% confidence interval (CI) 1.45-3.18; OR per +1 SD change in venular caliber=1.53, 95% CI 1.04-2.26).
We observed cross-sectional associations between retinal vessel caliber changes and metabolic syndrome and its components. We demonstrated that retinal vessel caliber assessments are feasible in health screening programs in a timely manner. Further longitudinal studies are warranted to determine whether retinal vessel caliber measurements can be used as noninvasive assessment to evaluate vascular health related to metabolic syndrome and cardiovascular diseases in health screening program.
视网膜微血管为评估活体微血管健康提供了直接手段。我们在一项健康筛查计划中研究了日本成年人的视网膜血管口径是否与代谢综合征的存在有关。
我们通过新田综合医院进行的健康筛查计划检查了 1003 名日本成年人。使用经过验证的半自动计算机辅助软件从数字眼底图像中测量视网膜血管口径。代谢综合征根据 2009 年联合临时声明提出的定义进行定义。使用多变量逻辑回归模型确定视网膜血管口径与代谢综合征或其各个成分之间的横断面关联作为比值比（OR）。
研究样本中代谢综合征的总体患病率为 29.9%。腰围增加、甘油三酯和血压升高的人视网膜动脉直径明显变窄。腰围增加的人视网膜静脉直径也变宽。视网膜动脉直径变窄和视网膜静脉直径变宽与代谢综合征的患病率较高相关（每标准偏差（SD）变化的视网膜小动脉口径的 OR=2.15，95%置信区间（CI）为 1.45-3.18；每 SD 变化的视网膜小静脉口径的 OR=1.53，95%CI 为 1.04-2.26）。
我们观察到视网膜血管口径变化与代谢综合征及其成分之间存在横断面关联。我们证明了在健康筛查计划中及时进行视网膜血管口径评估是可行的。需要进一步的纵向研究来确定视网膜血管口径测量是否可用于作为非侵入性评估来评估代谢综合征和心血管疾病相关的血管健康在健康筛查计划中。
