Lima-Fontes Mário, Barata Pedro, Falcão Manuel, Carneiro Ângela
Department of Ophthalmology, Centro Hospitalar Universitário de São João.
Department of Biomedicine, Faculty of Medicine.
Porto Biomed J. 2020 Dec 3;5(6):e104. doi: 10.1097/j.pbj.0000000000000104. eCollection 2020 Nov-Dec.
Metabolic syndrome (MetS) has emerged as a worldwide health hazard of the modern lifestyle, representing a cluster of metabolic abnormalities and a risk factor for cardiovascular disease. Eye diseases, such as diabetic retinopathy, central retinal artery occlusion, cataract, age-related macular degeneration, glaucoma, and dry eye syndrome have been linked with many of MetS components. Their relationship with MetS itself is, however, a recent topic of investigation. This review aims to gather published evidence supporting associations between ocular findings and MetS and to explore the related physiopathological processes that congregate in this syndrome and lead to these diseases. Despite compiling interesting and compelling evidence, it raises awareness to the need of further studies in this field to keep solidifying these associations and unveiling the pathological processes that support them. It ultimately targets MetS patients as a population of individuals who are at increased risk of developing age-related eye diseases and vision loss.
代谢综合征（MetS）已成为现代生活方式对全球健康的一大危害，它代表了一系列代谢异常情况，也是心血管疾病的一个风险因素。眼部疾病，如糖尿病性视网膜病变、视网膜中央动脉阻塞、白内障、年龄相关性黄斑变性、青光眼和干眼症，已与代谢综合征的许多组成部分相关联。然而，它们与代谢综合征本身的关系是最近才开始研究的课题。这篇综述旨在收集已发表的证据，支持眼部检查结果与代谢综合征之间的关联，并探讨在该综合征中聚集并导致这些疾病的相关生理病理过程。尽管汇编了有趣且有说服力的证据，但它也提高了人们对该领域进一步研究的必要性的认识，以便不断巩固这些关联并揭示支持它们的病理过程。它最终将代谢综合征患者作为患年龄相关性眼病和视力丧失风险增加的人群。
