Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, No. 1 Dongjiao Min Xiang, Dongcheng District, Beijing, 100730, China.
Graefes Arch Clin Exp Ophthalmol. 2012 Dec;250(12):1755-63. doi: 10.1007/s00417-012-2109-2. Epub 2012 Sep 5.
Our purpose was to determine the relationship of metabolic syndrome (MetS) and its components with retinal microvascular abnormalities in a rural Chinese population.
The Handan Eye Study, a population-based survey, recruited 6,830 (90.4 % of eligible) rural Chinese ≥30 years of age. A diagnosis of metabolic syndrome was based on the International Diabetes Federation definition. Retinal microvascular signs and arteriolar and venular diameters were assessed from fundus photographs by graders who were trained at the Retinal Vascular Imaging Centre, University of Melbourne.
After adjusting for age, gender, and smoking status, 5,519 participants with MetS, or with the specific components of large waist circumference, elevated blood pressure (BP), or elevated fasting blood glucose (FG), were more likely to have retinopathy, arteriovenous nicking, focal arteriolar narrowing, enhanced arteriolar wall reflex, and generalized retinal arteriolar narrowing than those without MetS or the corresponding component. Individuals with elevated triglycerides were significantly more likely to have arteriovenous nicking and retinopathy.
These results show that individual components of MetS are associated with different retinal microvascular signs and with changes in retinal arteriolar and venular diameters.
我们的目的是确定代谢综合征（MetS）及其成分与视网膜微血管异常在农村中国人群中的关系。
邯郸市眼病研究是一项基于人群的调查，共招募了 6830 名（合格人数的 90.4%）年龄在 30 岁及以上的农村中国人。代谢综合征的诊断基于国际糖尿病联合会的定义。视网膜微血管病变的迹象以及动静脉直径是由在墨尔本大学视网膜血管成像中心接受培训的分级员从眼底照片中评估的。
在调整年龄、性别和吸烟状况后，5519 名患有代谢综合征或具有特定成分（大腰围、血压升高或空腹血糖升高）的患者比没有代谢综合征或相应成分的患者更有可能患有视网膜病变、动静脉交叉、局灶性小动脉狭窄、增强的小动脉壁反射和广泛的视网膜小动脉狭窄。甘油三酯升高的个体发生动静脉交叉和视网膜病变的可能性显著增加。
这些结果表明，代谢综合征的各个成分与不同的视网膜微血管异常以及视网膜小动脉和小静脉直径的变化有关。
