Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria, Catania, Italy.
Photochem Photobiol. 2011 Nov-Dec;87(6):1214-29. doi: 10.1111/j.1751-1097.2011.00978.x. Epub 2011 Aug 25.
This review focuses on damage photosensitized by the fluoroquinolone (FQ) antibacterial drugs. Different models are employed to study biosubstrate photodamage mediated by FQs (organisms, cells, isolated biomolecules and super molecules). Being that the effect of environment (polarity of the medium, ions, pH, binding with bio-molecules, etc.) is crucial in FQ photochemistry, photobiological reactions can be consequently dramatically influenced. Thus, the photosensitization processes induced by FQs are here discussed taking into account that such extensive and cross-targeted pathological implications request an excursus covering photosensitization in systems of increasing molecular complexity. In vivo and in vitro evidences for photoallergy, phototoxicity, photomutagenesis and photocarcinogenesis mediated by FQs are discussed.
这篇综述聚焦于氟喹诺酮（FQ）类抗菌药物光致损伤。采用不同模型研究了 FQs 介导的生物底物光损伤（生物体、细胞、分离生物分子和超分子）。由于环境（介质极性、离子、pH 值、与生物分子结合等）对 FQ 光化学的影响至关重要，因此，光生物反应会受到显著影响。因此，本文讨论了 FQs 诱导的光致敏化过程，考虑到这种广泛而跨靶的病理影响需要一个涵盖越来越复杂分子系统的光致敏化综述。本文还讨论了 FQs 介导的光过敏、光毒性、光致突变和光致癌作用的体内和体外证据。
