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探讨碳纳米管的免疫毒性。

Exploring the immunotoxicity of carbon nanotubes.

机构信息

School of Pharmaceutical Sciences, Shandong University, Jinan, China.

出版信息

Nanoscale Res Lett. 2008 Aug 20;3(8):271-7. doi: 10.1007/s11671-008-9153-1.

DOI:10.1007/s11671-008-9153-1
PMID:21771349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3244872/
Abstract

Mass production of carbon nanotubes (CNTs) and their applications in nanomedicine lead to the increased exposure risk of nanomaterials to human beings. Although reports on toxicity of nanomaterials are rapidly growing, there is still a lack of knowledge on the potential toxicity of such materials to immune systems. This article reviews some existing studies assessing carbon nanotubes' toxicity to immune system and provides the potential mechanistic explanation.

摘要

大规模生产的碳纳米管(CNTs)及其在纳米医学中的应用导致纳米材料对人类的暴露风险增加。尽管关于纳米材料毒性的报告迅速增加,但对于这些材料对免疫系统的潜在毒性仍缺乏了解。本文综述了一些评估碳纳米管对免疫系统毒性的现有研究,并提供了潜在的机制解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/eb62be0a81d4/1556-276X-3-271-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/7b7f0bfdcafa/1556-276X-3-271-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/6f62573df685/1556-276X-3-271-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/eb62be0a81d4/1556-276X-3-271-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/7b7f0bfdcafa/1556-276X-3-271-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/6f62573df685/1556-276X-3-271-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aef/3244872/eb62be0a81d4/1556-276X-3-271-3.jpg

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1
Exploring the immunotoxicity of carbon nanotubes.探讨碳纳米管的免疫毒性。
Nanoscale Res Lett. 2008 Aug 20;3(8):271-7. doi: 10.1007/s11671-008-9153-1.
2
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引用本文的文献

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Biomedical Applications of CNT-Based Fibers.基于碳纳米管纤维的生物医学应用。
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2
Influence of Carbon Nanotubes and Its Derivatives on Tumor Cells In Vitro and Biochemical Parameters, Cellular Blood Composition In Vivo.碳纳米管及其衍生物对体外肿瘤细胞和生化参数、体内细胞血液成分的影响。
Nanoscale Res Lett. 2018 Sep 12;13(1):286. doi: 10.1186/s11671-018-2689-9.
3
Carbon nanotubes as a novel tool for vaccination against infectious diseases and cancer.碳纳米管作为一种新型工具,可用于预防传染病和癌症的疫苗接种。

本文引用的文献

1
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type.功能化碳纳米管的细胞摄取与官能团和细胞类型无关。
Nat Nanotechnol. 2007 Feb;2(2):108-13. doi: 10.1038/nnano.2006.209. Epub 2007 Jan 28.
2
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes.暴露于碳纳米管的NADPH氧化酶缺陷型C57BL/6小鼠肺部中性粒细胞积聚增加,纤维化减少。
Toxicol Appl Pharmacol. 2008 Sep 1;231(2):235-40. doi: 10.1016/j.taap.2008.04.018. Epub 2008 Apr 30.
3
A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response.
J Nanobiotechnology. 2013 Sep 11;11:30. doi: 10.1186/1477-3155-11-30.
4
Raman spectroscopy analysis and mapping the biodistribution of inhaled carbon nanotubes in the lungs and blood of mice.拉曼光谱分析及吸入式碳纳米管在肺部和血液中的生物分布绘图。
J Appl Toxicol. 2013 Oct;33(10):1044-52. doi: 10.1002/jat.2796. Epub 2012 Oct 10.
5
Human stem cell neuronal differentiation on silk-carbon nanotube composite.人干细胞在丝-碳纳米管复合材料上的神经元分化
Nanoscale Res Lett. 2012 Feb 14;7(1):126. doi: 10.1186/1556-276X-7-126.
一种用于发现具有降低的蛋白质结合、细胞毒性和免疫反应的纳米管的纳米组合文库策略。
Nano Lett. 2008 Mar;8(3):859-65. doi: 10.1021/nl0730155. Epub 2008 Feb 21.
4
Single-walled carbon nanotubes can induce pulmonary injury in mouse model.单壁碳纳米管可在小鼠模型中诱发肺损伤。
Nano Lett. 2008 Feb;8(2):437-45. doi: 10.1021/nl0723634. Epub 2008 Jan 29.
5
Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model.在小鼠模型中,吸入的单壁碳纳米管分散性改善导致沉积模式和肺部反应的改变。
Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L87-97. doi: 10.1152/ajplung.00186.2007. Epub 2007 Nov 16.
6
Functionalized carbon nanotubes in drug design and discovery.药物设计与发现中的功能化碳纳米管
Acc Chem Res. 2008 Jan;41(1):60-8. doi: 10.1021/ar700089b. Epub 2007 Sep 15.
7
Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice.维生素E缺乏会增强C57BL/6小鼠体内由单壁碳纳米管诱导的肺部炎症反应和氧化应激。
Toxicol Appl Pharmacol. 2007 Jun 15;221(3):339-48. doi: 10.1016/j.taap.2007.03.018. Epub 2007 Mar 27.
8
Advances and prospects on biomolecules functionalized carbon nanotubes.生物分子功能化碳纳米管的研究进展与展望
J Nanosci Nanotechnol. 2007 Apr-May;7(4-5):1298-314. doi: 10.1166/jnn.2007.654.
9
Biological properties of carbon nanotubes.碳纳米管的生物学特性。
J Nanosci Nanotechnol. 2007 Apr-May;7(4-5):1284-97. doi: 10.1166/jnn.2007.655.
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Nanomedicine and nanotoxicology: two sides of the same coin.纳米医学与纳米毒理学:同一枚硬币的两面。
Nanomedicine. 2005 Dec;1(4):313-6. doi: 10.1016/j.nano.2005.10.003.