Department of Physiology, School of Medicine, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
Pharmacol Biochem Behav. 2011 Oct;99(4):743-8. doi: 10.1016/j.pbb.2011.06.027. Epub 2011 Jul 12.
Systemic administration of cannabidiol (CBD), a non-psychotomimetic compound from Cannabis sativa, attenuates the cardiovascular and behavioral responses to restraint stress. Although the brain structures related to CBD effects are not entirely known, they could involve brainstem structures responsible for cardiovascular control. Therefore, to investigate this possibility the present study verified the effects of CBD (15, 30 and 60 nmol) injected into the cisterna magna on the autonomic and behavioral changes induced by acute restraint stress. During exposure to restraint stress (1h) there was a significant increase in mean arterial pressure (MAP) and heart rate (HR). Also, 24h later the animals showed a decreased percentage of entries onto the open arms of the elevated plus-maze. These effects were attenuated by CBD (30 nmol). The drug had no effect on MAP and HR baseline values. These results indicate that intracisternal administration of CBD can attenuate autonomic responses to stress. However, since CBD decreased the anxiogenic consequences of restraint stress, it is possible that the drug is also acting on forebrain structures.
系统给予大麻素非致幻化合物大麻二酚（CBD），可减轻束缚应激引起的心血管和行为反应。虽然与 CBD 作用相关的脑结构尚不完全清楚，但它们可能涉及负责心血管控制的脑干结构。因此，为了研究这种可能性，本研究验证了 cisterna magna 内注射 CBD（15、30 和 60 nmol）对急性束缚应激引起的自主和行为变化的影响。在束缚应激（1 小时）期间，平均动脉压（MAP）和心率（HR）显著增加。此外，24 小时后，动物在高架十字迷宫的开放臂上的进入次数百分比降低。这些作用被 CBD（30 nmol）减弱。该药物对 MAP 和 HR 的基础值没有影响。这些结果表明，cisterna magna 内给予 CBD 可减轻应激引起的自主反应。然而，由于 CBD 减轻了束缚应激的焦虑后果，因此该药物也可能作用于前脑结构。
