ncRNA, Epigenetic and Genome Fluidity, Institut Curie, Centre de Recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Biochimie. 2011 Nov;93(11):1889-96. doi: 10.1016/j.biochi.2011.07.001. Epub 2011 Jul 12.
Pervasive transcription is now accepted to be a general feature of eukaryotic genomes, generating short and long non-coding RNAs (ncRNAs). Growing number of examples have shown that regulatory ncRNAs can control gene expression and chromatin domain formation. In this review, we discuss recent reports that show that Saccharomyces cerevisiae's genome also supports pervasive transcription, which is strongly controlled by RNA decay pathways and nucleosome positioning. We therefore propose that S. cerevisiae is an excellent model for studying large ncRNAs, which has already provided important examples of antisense-mediated transcriptional silencing.
普遍转录现在被认为是真核基因组的一个普遍特征，产生短链和长链非编码 RNA（ncRNA）。越来越多的例子表明，调控性 ncRNA 可以控制基因表达和染色质结构域的形成。在这篇综述中，我们讨论了最近的报道，表明酿酒酵母的基因组也支持普遍转录，这种转录受到 RNA 降解途径和核小体定位的强烈控制。因此，我们提出酿酒酵母是研究长链 ncRNA 的理想模型，它已经提供了反义介导的转录沉默的重要例子。
