Department of Surgery, Aga Khan University, Karachi, Pakistan.
Int J Surg. 2011;9(6):482-5. doi: 10.1016/j.ijsu.2011.07.001. Epub 2011 Jul 13.
The gallbladder specimens of patients who underwent cholecystectomy for symptomatic gallstones between 2003 and 2005 were evaluated for the presence of Intestinal Metaplasia. (IM) and its risk factors. IM was positive in 39% of 293 patients tested, and in the comparative analysis of 114 metaplasia positive versus 179 negative patients, a high risk was found in patients who were 60 years or older [adjusted odds ratio (aOR) = 3.0, 95% confidence interval (CI): 1.5, 6.2]. Other factors with aOR greater than 1 were moderate to excessive use of chilies (1.8) and ethnic origin of North India (1.7). Screening method has yet to be devised for early detection of gallbladder cancer by identifying metaplastic lesions early in life. We believe that large geographic variation and lifestyle environmental factors associated with the development of gallbladder metaplasia and cancer mortality are concealed in our study that needs to be further explored.
对 2003 年至 2005 年间因胆囊结石症状而行胆囊切除术的患者的胆囊标本进行了肠上皮化生（IM）及其危险因素的评估。在 293 例接受检测的患者中，有 39%呈阳性，在对 114 例化生阳性与 179 例阴性患者的对比分析中，发现 60 岁或以上的患者风险较高[调整后的优势比（aOR）=3.0，95%置信区间（CI）：1.5，6.2]。其他 OR 值大于 1 的因素包括中至大量食用辣椒（1.8）和北印度裔（1.7）。我们认为，通过早期发现生命早期的化生病变，还需要制定筛查方法来早期发现胆囊癌。我们的研究隐藏了与胆囊化生和癌症死亡率相关的大的地理变异和生活环境因素，需要进一步探讨。
