Arnold Suzanne V, Chan Paul S, Jones Philip G, Decker Carole, Buchanan Donna M, Krumholz Harlan M, Ho P Michael, Spertus John A
Saint Luke's Mid America Heart Institute, 4401 Wornall Road, Kansas City, MO 64111, USA.
Circ Cardiovasc Qual Outcomes. 2011 Jul;4(4):467-76. doi: 10.1161/CIRCOUTCOMES.110.960468.
Black patients with myocardial infarction (MI) have worse outcomes than white patients, including higher mortality rates, more angina, and worse quality of life. The Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) study was designed to examine whether racial differences in socioeconomic, clinical, genetic, metabolic, biomarker, or treatment characteristics mediate observed disparities in outcomes.
Between April 11, 2005, and December 31, 2008, 31 567 patients with MI were prospectively screened; 6152 had an eligible MI, and 4340 (71%) were enrolled from 24 US centers. Consenting patients had detailed chart abstractions of their medical history and processes of inpatient care, supplemented with a detailed baseline interview. Detailed genetic and metabolic data were obtained at hospital discharge in 2979 (69%) and 3013 patients (69%), respectively. In a subset of patients, blood and urine samples were obtained at 1 month (obtained in 27% of survivors) and blood samples at 6 months (obtained in 19% of survivors). Centralized follow-up interviews sought to quantify patients' postdischarge care and outcomes, with a focus on their health status (symptoms, function, and quality of life). At 1, 6, and 12 months, 23%, 27%, and 24%, respectively, were lost to follow-up. Vital status was available for 99% of patients at 12 months.
TRIUMPH is a novel MI registry with detailed information on patients' sociodemographic, clinical, treatment, health status, metabolic, and genetic characteristics. The wealth of patient data collected in TRIUMPH will provide unique opportunities to examine factors that may mediate racial differences in mortality and health status after MI and the complex interactions between genetic and environmental determinants of post-MI outcomes.
心肌梗死（MI）黑人患者的预后比白人患者差，包括更高的死亡率、更多的心绞痛以及更差的生活质量。急性心肌梗死患者健康状况潜在差异的转化研究（TRIUMPH）旨在研究社会经济、临床、遗传、代谢、生物标志物或治疗特征方面的种族差异是否介导了观察到的预后差异。
在2005年4月11日至2008年12月31日期间，对31567例心肌梗死患者进行了前瞻性筛查；6152例符合心肌梗死标准，4340例（71%）来自美国24个中心。同意参与的患者有其病史和住院治疗过程的详细病历摘要，并辅以详细的基线访谈。分别在2979例（69%）和3013例患者（69%）出院时获得了详细的遗传和代谢数据。在一部分患者中，在1个月时采集了血液和尿液样本（27%的幸存者），在6个月时采集了血液样本（19%的幸存者）。集中的随访访谈旨在量化患者出院后的护理和预后情况，重点关注他们的健康状况（症状、功能和生活质量）。在1个月、6个月和12个月时，分别有23%、27%和24%的患者失访。12个月时99%的患者有生命状态信息。
TRIUMPH是一个新型的心肌梗死登记系统，具有关于患者社会人口统计学、临床、治疗、健康状况、代谢和遗传特征的详细信息。TRIUMPH收集的丰富患者数据将为研究可能介导心肌梗死后死亡率和健康状况种族差异的因素以及心肌梗死后预后的遗传和环境决定因素之间的复杂相互作用提供独特机会。
