Agharkar Research Institute, Pune, India.
Int J Obes (Lond). 2011 Oct;35(10):1318-24. doi: 10.1038/ijo.2011.138. Epub 2011 Jul 19.
To evaluate the continuous metabolic syndrome score (cMetS) in Indian children and to investigate its relationship with the risk of carotid arterial stiffness.
Data on weight, height, mean arterial pressure, serum lipids, insulin, glucose, carotid intima-media thickness and stiffness parameters, that is, pulse wave velocity (PWV), elasticity modulus (Ep), stiffness index (β) and arterial compliance (AC), were assessed in 236 children (6-17 years) from Pune city, India. cMetS was computed using standardized Z-scores for metabolic syndrome (MS) components. cMetS cutoff was obtained by receiver operating characteristic curve analysis across MS components.
cMetS was lowest (-3.6±2.0) in normal children and highest (3.3±2.4) in MS children. cMetS increased progressively with number of risk components. The cutoff of cMetS yielding maximal sensitivity (80%) and specificity (94%) for predicting the presence of MS was -0.8 (area under the curve=0.921 (95% CI: 0.877-0.964)). In children with cMetS above -0.8, average PWV (4.3±0.6 m s(-1)), β (3.8±1.2) and Ep (50.4±14.5 kPa) were significantly higher than the respective values (3.7±0.5 m s(-1); 3.4±0.8; 37.0±10.0 kPa) in children with cMetS below -0.8, whereas AC was lower (1.2±0.5 mm(2) kPa(-1)) in children with cMetS above -0.8 as against AC (1.4±0.3 mm(2) kPa(-1)) in children with cMetS below -0.8 (P<0.05), demonstrating the risk of stiffness with increasing score. Pearson's correlation coefficients of cMetS with PWV (r=0.575), β (r=0.347), AC (r=-0.267) and Ep (r=0.530) were statistically significant (P<0.01).
Results demonstrate the usefulness of cMetS over individual MS components as a better tool for assessment of atherosclerotic risk in children.
评估印度儿童的连续代谢综合征评分（cMetS），并探讨其与颈动脉动脉僵硬度风险的关系。
在印度浦那市评估了 236 名儿童（6-17 岁）的体重、身高、平均动脉压、血清脂质、胰岛素、血糖、颈动脉内膜-中层厚度和僵硬度参数，即脉搏波速度（PWV）、弹性模量（Ep）、僵硬度指数（β）和动脉顺应性（AC）。使用代谢综合征（MS）成分的标准化 Z 分数计算 cMetS。通过受试者工作特征曲线分析 across MS 成分获得 cMetS 截断值。
正常儿童的 cMetS 最低（-3.6±2.0），MS 儿童的 cMetS 最高（3.3±2.4）。cMetS 随风险成分数量的增加而逐渐增加。cMetS 的截断值为-0.8（最大敏感性为 80%，特异性为 94%），可预测 MS 的存在（曲线下面积=0.921（95%CI：0.877-0.964））。在 cMetS 高于-0.8 的儿童中，平均 PWV（4.3±0.6 m/s）、β（3.8±1.2）和 Ep（50.4±14.5 kPa）显著高于 cMetS 低于-0.8 的相应值（3.7±0.5 m/s；3.4±0.8；37.0±10.0 kPa），而 cMetS 高于-0.8 的儿童的 AC（1.2±0.5 mm(2)kPa(-1)) 低于 cMetS 低于-0.8 的儿童的 AC（1.4±0.3 mm(2)kPa(-1))（P<0.05），表明评分升高与僵硬风险相关。cMetS 与 PWV（r=0.575）、β（r=0.347）、AC（r=-0.267）和 Ep（r=0.530）的 Pearson 相关系数具有统计学意义（P<0.01）。
结果表明，cMetS 优于单个 MS 成分，是评估儿童动脉粥样硬化风险的更好工具。
