• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

局部应用透明质酸治疗口腔溃疡

Topical hyaluronic Acid in the management of oral ulcers.

作者信息

Kapoor Pranav, Sachdeva Shabina, Sachdeva Silonie

机构信息

Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.

出版信息

Indian J Dermatol. 2011 May;56(3):300-2. doi: 10.4103/0019-5154.82485.

DOI:10.4103/0019-5154.82485
PMID:21772592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3132908/
Abstract

Hyaluronic acid is a hygroscopic macromolecule formed by the polymerisation of glucuronic acid and N-acetylglucosamine disaccharide. It is a primary component of the extracellular matrix in various body tissues. Ihe use of topical Hyaluronic acid in the treatment of oral ulcers has been recently reported. This article reviews the mechanism of action, indications and efficacy of topical Hyaluronic acid gel in the management of oral ulcers.

摘要

透明质酸是由葡萄糖醛酸和N-乙酰葡糖胺二糖聚合形成的一种吸湿大分子。它是各种身体组织细胞外基质的主要成分。最近有报道称局部使用透明质酸治疗口腔溃疡。本文综述了局部用透明质酸凝胶治疗口腔溃疡的作用机制、适应证和疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3b/3132908/dc0e23939792/IJD-56-300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3b/3132908/4d35547932c7/IJD-56-300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3b/3132908/dc0e23939792/IJD-56-300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3b/3132908/4d35547932c7/IJD-56-300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3b/3132908/dc0e23939792/IJD-56-300-g002.jpg

相似文献

1
Topical hyaluronic Acid in the management of oral ulcers.局部应用透明质酸治疗口腔溃疡
Indian J Dermatol. 2011 May;56(3):300-2. doi: 10.4103/0019-5154.82485.
2
The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease.局部应用0.2%透明质酸凝胶治疗复发性口腔溃疡的疗效：复发性阿弗他溃疡与白塞病口腔溃疡的比较
J Eur Acad Dermatol Venereol. 2008 May;22(5):590-5. doi: 10.1111/j.1468-3083.2007.02564.x. Epub 2007 Dec 17.
3
Systematic review: the efficacy of topical hyaluronic acid on oral ulcers.系统评价：局部透明质酸治疗口腔溃疡的疗效。
J Biol Regul Homeost Agents. 2017 Dec 27;31(4 Suppl 2):63-69.
4
[Hyaluronic acid and extracellular matrix: a primitive molecule?].[透明质酸与细胞外基质：一种原始分子？]
Ann Dermatol Venereol. 2010 Apr;137 Suppl 1:S3-8. doi: 10.1016/S0151-9638(10)70002-8.
5
Hyaluronic Acid Sodium Salt 0.2% Gel in the Treatment of a Recalcitrant Distal Leg Ulcer: A Case Report.0.2%透明质酸钠凝胶治疗顽固性小腿远端溃疡：病例报告
J Clin Aesthet Dermatol. 2017 Nov;10(11):49-51. Epub 2017 Nov 1.
6
Effects of topical hyaluronic acid on corneal wound healing in dogs: a pilot study.局部应用透明质酸对犬角膜伤口愈合的影响：一项初步研究。
Vet Ophthalmol. 2017 Mar;20(2):123-130. doi: 10.1111/vop.12379. Epub 2016 Apr 7.
7
Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects.透明质酸在皮肤疾病治疗与预防中的应用：分子生物学、药学及临床方面
Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):207-13. doi: 10.1159/000080213.
8
Preparation and applications of hyaluronic acid and its derivatives.透明质酸及其衍生物的制备与应用。
Int J Biol Macromol. 2019 Mar 15;125:478-484. doi: 10.1016/j.ijbiomac.2018.12.074. Epub 2018 Dec 8.
9
Chemical modification of hyaluronic acid by carbodiimides.碳二亚胺对透明质酸的化学修饰。
Bioconjug Chem. 1991 Jul-Aug;2(4):232-41. doi: 10.1021/bc00010a007.
10
Transient benefits for topical hyaluronic acid in recurrent aphthous ulceration.局部应用透明质酸对复发性阿弗他溃疡的短暂益处。
Evid Based Dent. 2007;8(2):52. doi: 10.1038/sj.ebd.6400498.

引用本文的文献

1
Hyaluronic acid and chondroitin sulfate-based medical devices: formulations, esophageal mucosal protection, and their place in the management of GERD.基于透明质酸和硫酸软骨素的医疗器械：制剂、食管黏膜保护及其在胃食管反流病管理中的地位。
Therap Adv Gastroenterol. 2025 Jun 11;18:17562848251337822. doi: 10.1177/17562848251337822. eCollection 2025.
2
Hyaluronic acid: Hope or hype in periodontics - A narrative review.透明质酸：牙周病学中的希望还是炒作——一篇叙述性综述
J Indian Soc Periodontol. 2024 Nov-Dec;28(6):614-620. doi: 10.4103/jisp.jisp_476_23. Epub 2025 Apr 3.
3
Complexation of α-Mangostin with γ-Cyclodextrin and Its Application in Alginate/Chitosan Hydrogel Mucoadhesive Film for Treatment of Recurrent Aphthous Stomatitis.

本文引用的文献

1
The efficacy of topical hyaluronic acid in the management of oral lichen planus.局部应用透明质酸治疗口腔扁平苔藓的疗效。
J Oral Pathol Med. 2009 Mar;38(3):299-303. doi: 10.1111/j.1600-0714.2008.00739.x.
2
Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study.与年龄匹配的对照组相比，口干女性患者唾液中透明质酸水平的初步研究。
Biomed Res. 2009 Feb;30(1):63-8. doi: 10.2220/biomedres.30.63.
3
Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions.
α-山竹黄酮与γ-环糊精的络合作用及其在藻酸盐/壳聚糖水凝胶粘膜粘附膜治疗复发性阿弗他口炎中的应用。
J Inflamm Res. 2025 Feb 15;18:2185-2204. doi: 10.2147/JIR.S482582. eCollection 2025.
4
Efficacy of Topical Application of Chum Salmon () Skin-derived Collagen Extracts in Improving Oral Traumatic Ulcer Healing.大麻哈鱼（）皮肤来源的胶原蛋白提取物局部应用对促进口腔创伤性溃疡愈合的疗效。
Contemp Clin Dent. 2024 Apr-Jun;15(2):124-128. doi: 10.4103/ccd.ccd_544_22. Epub 2024 Jul 10.
5
Effectiveness of hyaluronic acid in the management of oral lichen planus: a systematic review and meta-analysis.透明质酸在口腔扁平苔藓治疗中的有效性：一项系统评价和荟萃分析。
J Dent Anesth Pain Med. 2022 Dec;22(6):405-417. doi: 10.17245/jdapm.2022.22.6.405. Epub 2022 Nov 24.
6
Pharmacologic treatment of GERD in adolescents: Is esophageal mucosal protection an option?青少年胃食管反流病的药物治疗：食管黏膜保护是一种选择吗？
Therap Adv Gastroenterol. 2022 Aug 17;15:17562848221115319. doi: 10.1177/17562848221115319. eCollection 2022.
7
Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis.用于复发性阿弗他口炎的药物传递系统的演变。
Drug Des Devel Ther. 2021 Sep 27;15:4071-4089. doi: 10.2147/DDDT.S328371. eCollection 2021.
8
Mouthwash Containing Vitamin E, Triamcinolon, and Hyaluronic Acid Compared to Triamcinolone Mouthwash Alone in Patients With Radiotherapy-Induced Oral Mucositis: Randomized Clinical Trial.含维生素E、曲安奈德和透明质酸的漱口水与单独使用曲安奈德漱口水治疗放疗引起的口腔黏膜炎患者的比较：随机临床试验
Front Oncol. 2021 Mar 11;11:614877. doi: 10.3389/fonc.2021.614877. eCollection 2021.
9
A 61-Year-Old Woman with Chronic Iron-Deficiency Anemia Due to a Cameron Lesion and a Response to Oral Application of Combined Poloxamer 407 with Hyaluronic Acid and Chondroitin Sulfate Following Single Treatment with Pantoprazole: A Case Report.一位 61 岁女性因 Cameron 病变导致慢性缺铁性贫血，以及单次使用泮托拉唑治疗后联合应用聚氧乙烯 407 与透明质酸和硫酸软骨素的口服治疗反应：病例报告。
Am J Case Rep. 2021 Jan 21;22:e928021. doi: 10.12659/AJCR.928021.
10
Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease - efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation.随机临床试验：黏膜保护联合抑酸治疗非糜烂性反流病——基于透明质酸-硫酸软骨素的生物黏附制剂Esoxx的疗效
Aliment Pharmacol Ther. 2017 Mar;45(5):631-642. doi: 10.1111/apt.13914. Epub 2017 Jan 24.
聚乙烯吡咯烷酮-透明质酸钠凝胶（Gelclair）：一种用于治疗口腔黏膜炎及其他疼痛性口腔病变的生物黏附性口腔凝胶。
Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1449-54. doi: 10.1517/17425255.4.11.1449.
4
Sodium hyaluronate accelerates the healing process in tooth sockets of rats.透明质酸钠可加速大鼠牙槽窝的愈合过程。
Arch Oral Biol. 2008 Dec;53(12):1155-62. doi: 10.1016/j.archoralbio.2008.07.001. Epub 2008 Aug 9.
5
Hyaluronic acid and periodontitis.透明质酸与牙周炎
Acta Medica (Hradec Kralove). 2007;50(4):225-8.
6
The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease.局部应用0.2%透明质酸凝胶治疗复发性口腔溃疡的疗效：复发性阿弗他溃疡与白塞病口腔溃疡的比较
J Eur Acad Dermatol Venereol. 2008 May;22(5):590-5. doi: 10.1111/j.1468-3083.2007.02564.x. Epub 2007 Dec 17.
7
The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration.局部应用透明质酸治疗复发性阿弗他溃疡的疗效。
J Oral Pathol Med. 2006 Sep;35(8):461-5. doi: 10.1111/j.1600-0714.2006.00433.x.
8
Evaluation of the clinical behaviour of a polyvinylpyrrolidone and sodium hyalonurate gel (Gelclair) in patients subjected to surgical treatment with CO2 laser.对接受二氧化碳激光手术治疗的患者使用聚乙烯吡咯烷酮和透明质酸钠凝胶（Gelclair）的临床行为评估。
Int J Oral Maxillofac Surg. 2006 Jun;35(6):514-7. doi: 10.1016/j.ijom.2005.12.004. Epub 2006 Feb 23.
9
The clinical application of hyaluronic acid in gingivitis therapy.透明质酸在牙龈炎治疗中的临床应用。
Quintessence Int. 2005 Jul-Aug;36(7-8):531-8.
10
[The effect of "Oral Wet" for elderly people with xerostomia--the effect of oral rinse containing hialuronan].“口腔保湿剂”对老年口干症患者的影响——含透明质酸的口腔含漱液的效果
Kokubyo Gakkai Zasshi. 2005 Mar;72(1):106-10. doi: 10.5357/koubyou.71and72.106.