Higuchi Yasushi, Ansai Toshihiro, Awano Shuji, Soh Inho, Yoshida Akihiro, Hamasaki Tomoko, Kakinoki Yasuaki, Takehara Tadamichi
Division of Community Oral Health Science, Kyushu Dental College, Kitakyushu, Japan.
Biomed Res. 2009 Feb;30(1):63-8. doi: 10.2220/biomedres.30.63.
Little is known regarding the association between the level of hyaluronic acid (HA) in saliva and dry mouth status. The aim of this study was to evaluate the salivary levels of HA in female patients with dry mouth (perceived xerostomia and hyposalivation) and compare them with age-matched controls. We studied 46 females, and classified them into two groups based on perceived xerostomia and salivary flow rate, as well as a control group without symptoms. HA concentrations in unstimulated whole saliva were determined and a significant difference was found between the groups. The statistical association was stronger in patients (perceived xerostomia, normosalivation) administrated xerogenic drugs, while the HA levels in that group were significantly lower than those in the controls when converted to absolute amount of saliva per min. Within the limitations of the present study, patients with dry mouth had lower HA levels in saliva, which may serve as a marker of local dryness or oral mucosa lubrication.
关于唾液中透明质酸（HA）水平与口干状况之间的关联，目前所知甚少。本研究的目的是评估口干女性患者（自觉口干和唾液分泌减少）的唾液HA水平，并将其与年龄匹配的对照组进行比较。我们研究了46名女性，并根据自觉口干、唾液流速将她们分为两组，以及一个无症状的对照组。测定了非刺激性全唾液中的HA浓度，发现各组之间存在显著差异。在服用致口干药物的患者（自觉口干、唾液分泌正常）中，统计关联更强，而当换算为每分钟唾液的绝对量时，该组的HA水平显著低于对照组。在本研究的局限性范围内，口干患者的唾液HA水平较低，这可能作为局部干燥或口腔黏膜润滑的一个标志物。
