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透明质酸:牙周病学中的希望还是炒作——一篇叙述性综述

Hyaluronic acid: Hope or hype in periodontics - A narrative review.

作者信息

Sahu Priyanka P, Uppoor Ashita S, Nayak Sangeeta Umesh

机构信息

Department of Periodontology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

出版信息

J Indian Soc Periodontol. 2024 Nov-Dec;28(6):614-620. doi: 10.4103/jisp.jisp_476_23. Epub 2025 Apr 3.

DOI:10.4103/jisp.jisp_476_23
PMID:40313332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12043222/
Abstract

The use of novel and cutting-edge materials has always existed in dentistry. For many years, dentists have considered environmental and behavioral factors that affect disease and treatment response when making patient care decisions. Considering its superior biological qualities, hyaluronic acid (HA) has attracted a lot of attention in a variety of medical domains. Its applications in dentistry have been investigated in periodontology, oral surgery, and even restorative dentistry. In the realm of dentistry, HA has attracted a lot of interest as a prospective treatment with promising results. The optimism around HA's use in dentistry is examined in this research to determine whether it is supported by reliable data or whether it is the result of overstated assertions. This review article objectively assesses the potential advantages and restrictions of HA application in dental practices through a thorough evaluation of the pertinent literature and clinical data. The purpose of this study is to provide a fair evaluation of whether HA represents a beacon of hope or if it is primarily the result of unfounded hype by looking at its efficacy in various dental procedures and therapeutic uses.

摘要

新型前沿材料在牙科领域的应用由来已久。多年来,牙医在做出患者护理决策时,会考虑影响疾病和治疗反应的环境及行为因素。鉴于其卓越的生物学特性,透明质酸(HA)在多个医学领域都备受关注。其在牙科的应用已在牙周病学、口腔外科乃至修复牙科中得到研究。在牙科领域,HA作为一种前景可期、效果有望的治疗方法已引发广泛关注。本研究审视了围绕HA在牙科应用的乐观态度,以确定其是否有可靠数据支持,抑或是夸大其词的结果。这篇综述文章通过全面评估相关文献和临床数据,客观地评估了HA在牙科实践中的潜在优势和局限性。本研究的目的是通过考察HA在各种牙科手术和治疗用途中的疗效,对其究竟是希望之光还是主要源于毫无根据的炒作进行公正评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0279/12043222/f8bca0fa4de5/JISP-28-614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0279/12043222/f8bca0fa4de5/JISP-28-614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0279/12043222/f8bca0fa4de5/JISP-28-614-g001.jpg

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本文引用的文献

1
Clinical, histological, immunohistochemical, and biomolecular analysis of hyaluronic acid in early wound healing of human gingival tissues: A randomized, split-mouth trial.透明质酸在人牙龈组织早期伤口愈合中的临床、组织学、免疫组织化学及生物分子分析:一项随机、双侧对照试验
J Periodontol. 2023 Jul;94(7):868-881. doi: 10.1002/JPER.22-0338. Epub 2023 Feb 9.
2
Local delivery of hyaluronic acid as an adjunct to scaling and root planing in the treatment of chronic periodontitis in smokers and non-smokers: A clinical and microbiological study.透明质酸局部给药作为吸烟者和非吸烟者慢性牙周炎龈下刮治及根面平整辅助治疗的临床和微生物学研究
J Indian Soc Periodontol. 2022 Sep-Oct;26(5):471-477. doi: 10.4103/jisp.jisp_308_21. Epub 2022 Sep 1.
3
Hyaluronic Acid as an Adjunct to Coronally Advanced Flap Procedures for Gingival Recessions: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
透明质酸作为牙龈退缩的冠向复位瓣手术辅助治疗:一项随机临床试验的系统评价和荟萃分析
J Pers Med. 2022 Sep 19;12(9):1539. doi: 10.3390/jpm12091539.
4
A Review on Current Strategies for Extraction and Purification of Hyaluronic Acid.透明质酸提取与纯化策略的研究进展
Int J Mol Sci. 2022 May 27;23(11):6038. doi: 10.3390/ijms23116038.
5
Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation.透明质酸:炎症治疗的关键成分。
Biomolecules. 2021 Oct 15;11(10):1518. doi: 10.3390/biom11101518.
6
Combination of enamel matrix derivative and hyaluronic acid inhibits lipopolysaccharide-induced inflammatory response on human epithelial and bone cells.釉基质衍生物和透明质酸的联合抑制脂多糖诱导的人上皮细胞和骨细胞的炎症反应。
Clin Oral Investig. 2022 Feb;26(2):1773-1783. doi: 10.1007/s00784-021-04152-8. Epub 2021 Aug 30.
7
Comparative Evaluation of Two Hyaluronic Acid Gel Products for the Treatment of Interdental Papillary Defects.两种透明质酸凝胶产品治疗牙间乳头缺损的比较评估
Acta Stomatol Croat. 2020 Sep;54(3):227-237. doi: 10.15644/asc54/3/1.
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Int Wound J. 2020 Apr;17(2):394-404. doi: 10.1111/iwj.13285. Epub 2019 Dec 16.
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Effect of bFGF and fibroblasts combined with hyaluronic acid-based hydrogels on soft tissue augmentation: an experimental study in rats.碱性成纤维细胞生长因子与成纤维细胞联合透明质酸基水凝胶对软组织填充的影响:大鼠实验研究
Maxillofac Plast Reconstr Surg. 2019 Nov 6;41(1):47. doi: 10.1186/s40902-019-0234-0. eCollection 2019 Dec.
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Open Access Maced J Med Sci. 2019 Jun 14;7(11):1834-1840. doi: 10.3889/oamjms.2019.478. eCollection 2019 Jun 15.