Zhao Jianhua, Grant Struan F A
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
J Obes. 2011;2011:845148. doi: 10.1155/2011/845148. Epub 2011 May 26.
Obesity is a major health problem and an immense economic burden on the health care systems both in the United States and the rest of the world. The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. To date, there have been only a few GWAS-related reports for childhood obesity specifically, with studies primarily uncovering loci in the adult setting instead. It is clear that a number of loci previously reported from GWAS analyses of adult BMI and/or obesity also play a role in childhood obesity.
肥胖是一个主要的健康问题，对美国乃至世界其他地区的医疗保健系统而言都是巨大的经济负担。在过去十年中，美国儿童和成人的肥胖患病率急剧上升。除环境因素外，已知遗传因素在肥胖的发病机制中起重要作用。全基因组关联研究（GWAS）已经揭示了与大多数常见疾病密切相关的基因组变异；事实上，独立研究小组普遍积极的重复研究结果对这些发现已达成普遍共识。迄今为止，专门针对儿童肥胖的GWAS相关报告仅有少数几篇，相关研究主要揭示的是成人肥胖的基因位点。很明显，先前GWAS分析成人BMI和/或肥胖所报告的许多基因位点也在儿童肥胖中起作用。
