Baig Ulfat, Belsare Prajakta, Watve Milind, Jog Maithili
Indian Institute of Science Education and Research, Pune 411021, India.
J Obes. 2011;2011:861049. doi: 10.1155/2011/861049. Epub 2011 May 5.
Obesity and related disorders are thought to have their roots in metabolic "thriftiness" that evolved to combat periodic starvation. The association of low birth weight with obesity in later life caused a shift in the concept from thrifty gene to thrifty phenotype or anticipatory fetal programming. The assumption of thriftiness is implicit in obesity research. We examine here, with the help of a mathematical model, the conditions for evolution of thrifty genes or fetal programming for thriftiness. The model suggests that a thrifty gene cannot exist in a stable polymorphic state in a population. The conditions for evolution of thrifty fetal programming are restricted if the correlation between intrauterine and lifetime conditions is poor. Such a correlation is not observed in natural courses of famine. If there is fetal programming for thriftiness, it could have evolved in anticipation of social factors affecting nutrition that can result in a positive correlation.
肥胖及相关疾病被认为源于代谢“节俭性”，这种特性是为了应对周期性饥饿而进化出来的。低出生体重与成年后肥胖之间的关联，使得人们的观念从节俭基因转变为节俭表型或胎儿期预期编程。节俭的假设在肥胖研究中是隐含的。在此，我们借助一个数学模型，研究节俭基因进化或节俭胎儿期编程的条件。该模型表明，节俭基因在种群中无法以稳定的多态状态存在。如果子宫内环境与终生环境之间的相关性较差，那么节俭胎儿期编程的进化条件就会受到限制。在自然饥荒过程中并未观察到这种相关性。如果存在节俭胎儿期编程，那么它可能是为了应对影响营养的社会因素而进化出来的，这些社会因素可能会导致正相关。
