Dean Nichole R, Sweeny Larissa, Magnuson J Scott, Carroll William R, Robinson Daniel, Desmond Renee A, Rosenthal Eben L
Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA.
J Skin Cancer. 2011;2011:972497. doi: 10.1155/2011/972497. Epub 2011 Jun 9.
Recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of the head and neck was performed (n = 72). Data regarding tumor site, stage, treatment, parotid involvement, perineural invasion, positive margins, metastasis, and disease-free survival was analyzed. The majority of patients were male (85%) and presented with recurrent stage III (89%) cSCC. Two-year disease-free survival was 62% and decreased to 47% at 5 years. Parotid involvement, positive margins, nodal metastasis, or the presence of perineural invasion did not correlate with decreased survival (P > .05). Distant metastasis was a strong indicator of poor overall survival (P < .001). Adjuvant postoperative radiotherapy did not improve overall survival (P = .42). Overall survival was poor for patients with advanced recurrent cSCC despite the combined treatment with surgery and radiotherapy.
复发性晚期皮肤鳞状细胞癌（cSCC）并不常见，关于患者预后的出版物有限。我们进行了一项回顾性研究，纳入了因复发性晚期头颈部cSCC接受手术切除的患者（n = 72）。分析了有关肿瘤部位、分期、治疗、腮腺受累、神经周围侵犯、切缘阳性、转移和无病生存期的数据。大多数患者为男性（85%），表现为复发性III期（89%）cSCC。两年无病生存率为62%，5年时降至47%。腮腺受累、切缘阳性、淋巴结转移或神经周围侵犯的存在与生存率降低无关（P > 0.05）。远处转移是总体生存不良的有力指标（P < 0.001）。辅助性术后放疗并未改善总体生存率（P = 0.42）。尽管采用了手术和放疗联合治疗，但晚期复发性cSCC患者的总体生存率仍较差。
