Department of Orthopaedics, Erasmus MC, University Medical Center Rotterdam, Dr. Molenwaterplein 40, Room 16.14, PO box 2040, 3000 CA Rotterdam, The Netherlands.
J Bone Miner Metab. 2012 Jan;30(1):40-6. doi: 10.1007/s00774-011-0293-5. Epub 2011 Jul 20.
Mechanical loading has stimulating effects on bone architecture, which can potentially be used as a therapy for osteoporosis. We investigated the skeletal changes in the tibia of ovariectomized rats during treatment with whole body vibration (WBV). Different low-magnitude WBV treatment protocols were tested in a pilot experiment using ovariectomized rats with loading schemes of 2 × 8 min/day, 5 days/week (n = 2 rats per protocol). Bone volume and architecture were evaluated during a 10 week follow-up using in-vivo microcomputed tomography scanning. The loading protocol in which a 45 Hz sine wave was applied at 2 Hz with an acceleration of 0.5g showed an anabolic effect on bone and was therefore further analyzed in two groups of animals (n = 6 each group) with WBV starting directly after or 3 weeks after ovariectomy and compared to a control (non-WBV) group at 0, 3, 6 and 10 weeks' follow-up. In the follow-up experiment the WBV stimulus did not significantly affect trabecular volume fraction or cortical bone volume in any of the treatment groups during the 10 week follow-up. WBV did reduce weight gain that was induced as a consequence of ovariectomy. We could not demonstrate any significant effects of WBV on bone loss as a consequence of ovariectomy in rats; however, the weight gain that normally results after ovariectomy was partly prevented. Treatment with WBV was not able to prevent bone loss during induced osteoporosis.
机械负荷对骨骼结构具有刺激作用，可潜在地用于治疗骨质疏松症。我们研究了全身振动（WBV）治疗期间去卵巢大鼠胫骨的骨骼变化。在使用去卵巢大鼠的初步实验中测试了不同的低幅度 WBV 治疗方案，负荷方案为每天 2×8 分钟，每周 5 天（每个方案 2 只大鼠）。在 10 周的随访期间，使用体内微计算机断层扫描评估骨体积和结构。应用频率为 45 Hz、加速度为 0.5g 的正弦波，以 2 Hz 的频率加载的方案显示出对骨骼的合成代谢作用，因此将其进一步在两组动物（每组 6 只）中进行分析，一组在去卵巢后立即开始进行 WBV，另一组在 3 周后开始进行 WBV，并与对照组（非 WBV）进行比较，在 0、3、6 和 10 周的随访中进行比较。在后续实验中，在 10 周的随访中，WBV 刺激并未显著影响任何治疗组的小梁体积分数或皮质骨体积。WBV 确实减少了因去卵巢引起的体重增加。我们未能证明 WBV 对去卵巢大鼠骨质疏松症引起的骨丢失有任何显著影响；然而，部分预防了通常因去卵巢引起的体重增加。WBV 治疗不能预防诱导性骨质疏松症期间的骨丢失。
