Department of Microbiology and Immunology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
Mod Rheumatol. 2012 Apr;22(2):308-11. doi: 10.1007/s10165-011-0500-1. Epub 2011 Jul 20.
A 41-year-old woman presented with continuous fever, and her laboratory data suggested the recrudescence of systemic lupus erythematosus. She was treated with 60 mg/day prednisolone. With a dose reduction of prednisolone, high fever and pancytopenia were observed again. A bone marrow biopsy revealed hemophagocytosis. The effects of steroid pulse therapy, high-dose intravenous immunoglobulin, cyclosporine A, and methotrexate were insufficient. However, after four injections of etanercept (25 mg, twice a week) subcutaneously, her symptoms had completely resolved. In such cases, therapy with etanercept may be effective.
一位 41 岁女性因持续发热就诊，实验室数据提示系统性红斑狼疮复发。给予她泼尼松龙 60mg/天治疗。随着泼尼松龙剂量的减少，再次出现高热和全血细胞减少。骨髓活检显示噬血细胞现象。虽然给予了激素冲击治疗、大剂量静脉注射免疫球蛋白、环孢素 A 和甲氨蝶呤治疗，但效果不佳。然而，皮下注射依那西普（25mg，每周两次，共 4 次）后，她的症状完全缓解。在这种情况下，依那西普治疗可能有效。
