Takahashi Nobuyuki, Naniwa Taio, Banno Shogo
Fourth Department of Internal Medicine, Nagoya Higashi Municipal Hospital, Nagoya, Japan.
Mod Rheumatol. 2008;18(1):72-5. doi: 10.1007/s10165-007-0006-z. Epub 2007 Dec 27.
Hemophagocytic syndrome has been reported to be associated with systemic lupus erythematosus. A 25-year-old woman with systemic lupus erythematosus developed hemophagocytic syndrome that was refractory to the combination therapy with high-dose corticosteroid, cyclosporine, and high-dose intravenous immunoglobulin, and successfully treated with the tumor necrosis factor inhibitor, etanercept. This case report provided the first observation that etanercept may be useful for the treatment of hemophagocytic syndrome associated with systemic lupus erythematosus refractory to conventional therapy.
据报道，噬血细胞综合征与系统性红斑狼疮有关。一名25岁的系统性红斑狼疮女性患者出现了噬血细胞综合征，该综合征对大剂量皮质类固醇、环孢素和大剂量静脉注射免疫球蛋白的联合治疗无效，但使用肿瘤坏死因子抑制剂依那西普成功治愈。本病例报告首次观察到依那西普可能对治疗常规治疗无效的系统性红斑狼疮相关噬血细胞综合征有用。
