Staicu M L, Mureşan A, Tache S, Moldovan R
Department of Medical Psychology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
J Med Life. 2011 May 15;4(2):163-7. Epub 2011 May 25.
The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice.
For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).
Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous.
In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy.
本研究评估了孕期两种抗氧化因子——维生素E和辅酶Q10——对妊娠的氧化应激影响，旨在将结果应用于进一步的人类临床实践。
对于我们所研究的每个方面，我们使用了三种类型的Wistar品系雌性大鼠（未怀孕、初产、经产），每组分为10只大鼠。从采集的血液中，我们测定了氧化应激（OS）标志物：丙二醛（MDA）和羰基化蛋白（CP），以及抗氧化防御标志物：血浆氢供体能力（HD）和巯基（SH）。
给予维生素E可使初产大鼠的MDA显著降低，CP和HD显著升高，经产大鼠的SH基团也显著增加。在接受抗氧化复合物中辅酶Q10的怀孕动物中，我们观察到初产大鼠的氧化应激（OS）——MDA增加，经产大鼠的CP增加。
就维生素E而言，考虑到其对氧化还原稳态的益处以及OS的降低，作者建议在孕期补充维生素E。然而，由于怀孕动物中OS增加，作者不建议在孕期给予抗氧化复合物中的辅酶Q10。
