Biopolymers and Colloids Research Laboratory, Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Food Funct. 2010 Oct;1(1):32-59. doi: 10.1039/c0fo00111b. Epub 2010 Sep 24.
There is increasing interest in understanding and controlling the digestion of emulsified lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are being developed to encapsulate, protect, and release non-polar lipids, vitamins, nutraceuticals, and drugs. These delivery systems are also being used to control the stability and digestion of lipids within the human gastrointestinal tract so as to create foods that enhance satiety and reduce hunger. In vitro digestion models are therefore needed to test the efficacy of different approaches of controlling lipid digestion under conditions that simulate the human gastrointestinal tract. This article reviews the current status of in vitro digestion models for simulating lipid digestion, with special emphasis on the pH stat method. The pH stat method is particularly useful for the rapid screening of food emulsions and emulsion-based delivery systems with different compositions and structures. Successful candidates can then be tested with more rigorous in vitro digestion models, or using animal or human feeding studies.
人们越来越关注理解和控制食品和制药行业中乳化脂质的消化。基于乳液的输送系统正在被开发出来，以封装、保护和释放非极性脂质、维生素、营养保健品和药物。这些输送系统也被用于控制人胃肠道内脂质的稳定性和消化，以创造出增强饱腹感和减少饥饿感的食品。因此，需要体外消化模型来测试不同控制脂质消化方法在模拟人胃肠道条件下的功效。本文综述了模拟脂质消化的体外消化模型的现状，特别强调了 pH -stat 法。pH-stat 法特别适用于快速筛选具有不同组成和结构的食品乳液和乳液基输送系统。然后可以使用更严格的体外消化模型或动物或人体喂养研究来测试成功的候选物。
