多灶性黏膜扁平苔藓患者血清中 miRNA 表达的变化及其与疾病持续时间的相关性。
Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus.
机构信息
Department of Public Health and Clinical Medicine/Dermatology and Venereology, Umeå University, Umeå, Sweden.
出版信息
J Oral Pathol Med. 2012 Jan;41(1):86-9. doi: 10.1111/j.1600-0714.2011.01063.x. Epub 2011 Jul 21.
BACKGROUND
Mucosal lichen planus is a severe variant of lichen planus, Lichen planus (LP), which in many ways affect patients' lives. The aetiology is not fully understood, and there is no treatment clearing the disease once and for all. Oral LP has by the WHO been classified as a precancerous lesion. Micro-RNAs, miRNAs, are non-coding, small single-stranded RNAs involved in biological processes like apoptosis, proliferation, differentiation, metastasis, angiogenesis and immune response.
METHODS AND RESULTS
In sera from 30 patients with multifocal mucosal LP, 15 miRNAs were identified as significantly differentially expressed compared with controls. The three most up-regulated miRNAs are all connected to oral squamous cell carcinoma or epithelial carcinoma in general.
DISCUSSION
Even if no specific LP-associated miRNA profile was found, data clearly indicate that miRNAs could play a role in the earlier phases of lichen planus.
背景
黏膜扁平苔藓是扁平苔藓（LP）的一种严重变异，在很多方面影响着患者的生活。其病因尚未完全阐明，也没有能够一劳永逸地清除疾病的治疗方法。世界卫生组织已将口腔扁平苔藓归类为癌前病变。微小 RNA（miRNA）是非编码的、小的单链 RNA，参与凋亡、增殖、分化、转移、血管生成和免疫反应等生物学过程。
方法和结果
在 30 例多灶性黏膜扁平苔藓患者的血清中，与对照组相比，有 15 种 miRNA 被鉴定为显著差异表达。上调最明显的三种 miRNA 均与口腔鳞状细胞癌或上皮癌有关。
讨论
即使没有发现特定的 LP 相关 miRNA 谱，但数据清楚地表明 miRNA 可能在扁平苔藓的早期阶段发挥作用。
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