微小RNA在口腔苔藓样病变中的作用。系统评价。
The role of microRNAs in oral lichenoid disorders. Systematic review.
作者信息
Setién-Olarra A, Gainza-Cirauqui M-L, Aguirre-Urizar J-M, Marichalar-Mendia X
机构信息
Oral Medicine, Oral and Maxillofacial Pathology. Department of Stomatology II, University of the Basque Country/ EHU, Leioa, 48940 Bizkaia, Spain,
出版信息
Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e548-e553. doi: 10.4317/medoral.21819.
BACKGROUND
Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD).
MATERIAL AND METHODS
A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA.
RESULTS
Originally, 25 articles were considered, of which 12 case-control articles were selected according to the inclusion/exclusion criteria.
CONCLUSIONS
OLD seems to have altered microRNA expression profile. Certain altered microRNAs (146a, 155) may be useful as biomarkers for this disorder. More studies including larger number of cases are needed in order to study further on the biological processes and on the regulation pathways of these altered microRNAs.
背景
微小RNA表达的某些变化被认为与慢性炎症过程以及口腔潜在恶性疾病的恶性转化有关。本系统评价的目的是更新关于口腔苔藓样病（OLD）中异常微小RNA表达谱的现有数据。
材料与方法
使用以下关键词在PubMed-Medline和Scopus中检索2010年至2016年8月发表的英文文献：口腔苔藓样病、扁平苔藓和微小RNA。
结果
最初筛选出25篇文章，根据纳入/排除标准选择了其中12篇病例对照文章。
结论
OLD似乎具有改变的微小RNA表达谱。某些改变的微小RNA（146a、155）可能作为该疾病的生物标志物。需要更多纳入大量病例的研究，以便进一步研究这些改变的微小RNA的生物学过程和调控途径。
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