School of Biomedical Sciences, University of Nottingham, England, UK.
Exp Parasitol. 2011 Oct;129(2):207-10. doi: 10.1016/j.exppara.2011.06.017. Epub 2011 Jul 13.
In addition to the possible role of Acanthamoeba as an evolutionary precursor of pathogenicity in microbial pathogens, it has been suggested that intracellular bacteria or other microbial endosymbionts may also enhance the pathogenicity of Acanthamoeba. Using transmission electron microscopy, polymerase chain reaction and simple culturing, our findings did not reveal any apparent evidence of microbial presence intracellularly of a recently recovered clinical isolate of Acanthamoeba. Based on these findings, it is tempting to speculate that the virulence of Acanthamoeba may not be attributed to the pathogenicity of the endosymbiont alone.
除了棘阿米巴可能作为微生物病原体致病进化前体的作用外，还有人认为细胞内细菌或其他微生物内共生体也可能增强棘阿米巴的致病性。通过透射电子显微镜、聚合酶链反应和简单培养，我们的研究结果没有发现任何明显的证据表明最近回收的棘阿米巴临床分离株的细胞内有微生物存在。基于这些发现，人们不禁推测，棘阿米巴的毒力可能不是归因于内共生体的致病性。
